The Effects of GCSF on the Recovery Time and Duration of Hospitalization in Patients with Anti-thyroid Drug-Induced Agranulocytosis in a Tertiary Hospital

Authors

  • Maria Monina Clauna-Lumanta The Medical City
  • Christy Yao The Medical City
  • Johann Fabrian Bolinao The Medical City

Keywords:

antithyroid drugs, agranulocytosis, granulocyte colony-stimulating factor, hyperthyroidism

Abstract

Objectives. This study aims to determine if there is a significant difference in the recovery time and duration of hospital stay of patients with anti-thyroid drug-(ATD) induced agranulocytosis with and without granulocyte colony-stimulating factor (GCSF) therapy. It also aims to describe the clinical characteristics of patients who had anti-thyroid drug-induced agranulocytosis.

Methodology. This is a retrospective study of hyperthyroid patients on anti-thyroid drugs (ATD) who had an absolute neutrophil count (ANC) of less than 500/μL. Their charts were reviewed for collection of data on age, gender, body mass index (BMI), type and duration of ATD and use of antibiotic and steroid. Recovery time and length of hospital stay were compared between those who received and did not receive GCSF.

Results. TWith similar clinical features between the GCSF and non-GCSF groups, the recovery time from agranulocytosis and duration of hospitalization were significantly shorter in the GCSF group, despite lower ANC.

Conclusion. GCSF significantly decreased recovery time (4 versus 7 days, p=0.005) and duration of hospital stay (5 versus 7 days, p=0.009) of hyperthyroid patients with anti-thyroid drug-induced agranulocytosis compared to patients not given GCSF.

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Author Biographies

Maria Monina Clauna-Lumanta, The Medical City

Graduate of Endocrinology Fellowship Training

Section of Endocrinology, Diabetes and Metabolism

Department of Medicine 

The Medical City

and

Active Consultant

Deparment of Medicine

New Sinai MDI Hospital

Christy Yao, The Medical City

Training Officer

Section of Endocrinology, Diabetes and Metabolism

Department of Medicine

Johann Fabrian Bolinao, The Medical City

Former Associate Head

Center for Research and Healthcare Innovation

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Published

2016-11-06

How to Cite

Clauna-Lumanta, M. M., Yao, C., & Bolinao, J. F. (2016). The Effects of GCSF on the Recovery Time and Duration of Hospitalization in Patients with Anti-thyroid Drug-Induced Agranulocytosis in a Tertiary Hospital. Journal of the ASEAN Federation of Endocrine Societies, 31(2), 131. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/298

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Section

Original Articles