Differences in the Insulin Resistance Levels Measured by HOMA-IR between Patients with Erosive and Non-Erosive Gastroesophageal Reflux Disease

Authors

  • Laras Budiyani Faculty of Medicine Universitas Indonesia http://orcid.org/0000-0003-4436-9240
  • Dyah Purnamasari Metabolic Endocrinology Division Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital http://orcid.org/0000-0002-9277-434X
  • Marcellus Simadibrata Gastroenterology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital http://orcid.org/0000-0003-1131-5836
  • Murdani Abdullah Clinical Epidemiology Unit Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital http://orcid.org/0000-0002-8801-0283

Keywords:

insulin resistance, erosive esophagitis, esophageal erosion, HOMA-IR

Abstract

Background. Insulin resistance is the core of Metabolic Syndrome which carries a high risk for cardiovascular events. Insulin resistance had been reported to be higher in GERD patients than subjects without GERD, specifically in erosive esophagitis.

Objective. To compare the degree of insulin resistance, using HOMA-IR index, between erosive and non-erosive reflux disease.

Methodology. A cross-sectional study of 84 adult patients with GERD symptoms was conducted. The subjects were recruited consecutively between January 2017 and April 2017 at Cipto Mangunkusumo National Hospital in Jakarta. Gastroesophageal Reflux Disease Questionnaire (GERDQ) was used for subject recruitment. Homeostatic model assessment-insulin resistance (HOMA-IR) index was used to evaluate insulin sensitivity. Esophageal erosions were diagnosed using upper gastrointestinal endoscopy. Bivariate analysis was used to determine HOMA-IR difference between esophagitis and non-esophagitis group.

Results. The median of HOMA-IR in all subjects was 1.46 (0.32-13.85). Mann-Whitney test revealed that HOMA-IR index was higher in patients with erosive esophagitis [median 1.74 (0.35-13.85)] than those without erosive esophagitis [median 1.21 (0.32-10.78)] (p=0.05).

Conclusion. Insulin resistance is significantly higher in gastroesophageal reflux disease patients with esophageal erosions than in those without esophageal erosion.

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Published

2017-09-07

How to Cite

Budiyani, L., Purnamasari, D., Simadibrata, M., & Abdullah, M. (2017). Differences in the Insulin Resistance Levels Measured by HOMA-IR between Patients with Erosive and Non-Erosive Gastroesophageal Reflux Disease. Journal of the ASEAN Federation of Endocrine Societies, 32(2), 139. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/416

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