Bone Metabolism and Fracture Risk in Diabetes Mellitus

Authors

  • Melisa Diah Puspitasari Department of Internal Medicine, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia http://orcid.org/0000-0001-5936-1183
  • Dyah Purnamasari Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia http://orcid.org/0000-0002-9277-434X
  • Bambang Setyohadi Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia http://orcid.org/0000-0001-8321-0270
  • Harry Isbagio Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia http://orcid.org/0000-0001-9169-8536

Keywords:

bone metabolism, diabetes mellitus, bone remodeling, biomarkers

Abstract

Individuals with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are at increased risk for fragility fractures. Bone mineral density (BMD) is decreased in T1DM but often normal or even elevated in T2DM when compared with age-matched non-DM populations. However, bone turnover is decreased in both T1DM and T2DM. The pathophysiologic mechanisms leading to bone fragility is multifactorial, and potentially leads to reduced bone formation, altered bone microstructure and decreased bone strength. Interestingly, different antidiabetic treatments may influence fracture risk due to effects on glycemic control, triggering of hypoglycemic events or osteoblastogenesis.

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Author Biographies

Melisa Diah Puspitasari, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Department of Internal Medicine, resident

Dyah Purnamasari, Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Division of Metabolism and Endocrinology, Department of Internal Medicine, staff

Bambang Setyohadi, Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Division of Rheumatology, Department of Internal Medicine, staff

Harry Isbagio, Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Division of Rheumatology, Department of Internal Medicine, Professor

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Published

2017-10-15

How to Cite

Puspitasari, M. D., Purnamasari, D., Setyohadi, B., & Isbagio, H. (2017). Bone Metabolism and Fracture Risk in Diabetes Mellitus. Journal of the ASEAN Federation of Endocrine Societies, 32(2), 90. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/431

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