A Systematic Review on the Association between Lipid Accumulation Product Index and Type 2 Diabetes Mellitus

Gratcia Ayundini, Cindy Astrella, Dicky Tahapary, Pradana Soewondo

Abstract

Introduction. Excess of fat accumulation contributes to the development of type 2 diabetes mellitus (T2DM). Lipid accumulation product (LAP) index is an index computed from waist circumference and triglycerides, which represents increased lipotoxicity. We aim to study the relationship of LAP index and T2DM and its potency as a predictor for T2DM development.

Methodology. All studies retrieved during literature search in PubMed and Cochrane database using the terms of lipid accumulation product, LAP and T2DM reporting the association between LAP and T2DM were reviewed.

Results. Two cross-sectional studies and 1 cohort study in Japan, USA and Iran respectively were obtained. In Japan, the cut off values were different, 21.1 for women and 37.2 for men. A high LAP corresponds to a higher risk of T2DM [19.1 (6.6 – 55.5) for women and 7.4 (5.1 – 10.8) for men].

Conclusion. LAP has strong association with T2DM but its ability to predict the incidence of T2DM needs to be confirmed.

Keywords

lipid accumulation product; type 2 diabetes mellitus; insulin resistance, obesity

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Abstract