THE VERY LOW CARBOHYDRATE DIET (VLCBD)

SHORT-TERM METABOLIC EFFICACY IN DIABETIC KIDNEY DISEASE PATIENTS

Authors

  • Nur Aisyah Zainordin UiTM Sungai Buloh, Malaysia
  • Nur Aini Eddy Warman UiTM Sungai Buloh, Malaysia
  • Aimi Fadhilah Mohamad UiTM Sungai Buloh, Malaysia
  • Fatin Aqilah Abu Yazid UiTM Sungai Buloh, Malaysia
  • Nazrul Hadi Ismail UiTM Puncak Alam, Malaysia
  • Chen Xin Wee UiTM Sungai Buloh, Malaysia
  • Thuhairah Hasrah Abd Rahman UiTM Sungai Buloh, Malaysia
  • Marymol Koshy UiTM Sungai Buloh, Malaysia
  • Mazuin Mohd Razalli UiTM Sungai Buloh, Malaysia
  • Rohana Abd Ghani UiTM Sungai Buloh, Malaysia

DOI:

https://doi.org/10.15605/jafes.036.S7

Keywords:

carbohydrate diet, metabolic, diabetic

Abstract

INTRODUCTION
Obesity is strongly linked to the development of diabetic kidney disease. While very low carbohydrate diet (VLCBD) was associated with weight reduction, its effects on patients with diabetic kidney disease (DKD) are not well known. The aim of the study was to determine the metabolic effects of VLCBD in DKD patients.


METHODOLOGY
30 patients with type 2 diabetes aged 40 to 75 years and HbA1c of 7 to 10.5% were randomly allocated to receive VLCBD (<20 g/day) versus standard low protein diet (LPD) (0.8 g/kg/day). The patients received consultations every two weeks for 12 weeks. Metabolic profiles, glycemic control, inflammatory markers and visceral adipose tissue mass were compared.


RESULTS
The VLCBD group demonstrated significant reductions in weight [-4.0 interquartile range (IQR) 3.9 versus 0.2 IQR 4.2 kg, p=<0.001] and body mass index (-1.5 IQR 1.18 versus 0.074 IQR 1.54 kg/m2, p=<0.001) compared to the LPD group. Wais circumferences were reduced in both groups (-4.0 IQR 5.25, p=0.003 and -2.0 IQR 3.6 cm, p=0.009). Estimated visceral adipose tissue mass and volume were significantly reduced in the VLCBD group. There were no significant changes in liver ultrasonographic findings in both groups. Both groups also showed a reduction in HbA1c (-1.3 IQR 1.1 versus -0.7 IQR 1.25%, p=NS). There was a significant increment in LDL in the VLCBD. The VLCBD group showed a significant reduction in IL-6 levels (-1.53 IQR 3.35 versus 0.46 IQR 1.95 pg/mL, p=0.028). Patients in VLCBD appeared to have an improvement in physical activity score compared to the LPD group.


CONCLUSION
After short-term intensive VLCBD intervention in DKD patients, improvements were observed in metabolic markers, diabetes status and inflammatory markers, supported by improvement in physical activity.

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Author Biographies

Nur Aisyah Zainordin, UiTM Sungai Buloh, Malaysia

Endocrine

Nur Aini Eddy Warman, UiTM Sungai Buloh, Malaysia

Endocrine

Aimi Fadhilah Mohamad, UiTM Sungai Buloh, Malaysia

Endocrine

Fatin Aqilah Abu Yazid, UiTM Sungai Buloh, Malaysia

Endocrine

Nazrul Hadi Ismail, UiTM Puncak Alam, Malaysia

Centre of Dietetics Studies

Chen Xin Wee, UiTM Sungai Buloh, Malaysia

Public Health Medicine

Thuhairah Hasrah Abd Rahman, UiTM Sungai Buloh, Malaysia

Pathology

Marymol Koshy, UiTM Sungai Buloh, Malaysia

Radiology

Mazuin Mohd Razalli, UiTM Sungai Buloh, Malaysia

Radiology

Rohana Abd Ghani, UiTM Sungai Buloh, Malaysia

Endocrine

References

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Published

2021-07-28

How to Cite

Zainordin, N. A., Warman, N. A. E., Mohamad, A. F., Yazid, . F. A. A., Ismail, . N. . H. ., Wee, C. X. ., Rahman, T. H. A., Koshy, . M. ., Razalli, M. M., & Ghani, R. A. . (2021). THE VERY LOW CARBOHYDRATE DIET (VLCBD): SHORT-TERM METABOLIC EFFICACY IN DIABETIC KIDNEY DISEASE PATIENTS. Journal of the ASEAN Federation of Endocrine Societies, 36, 7. https://doi.org/10.15605/jafes.036.S7

Issue

Section

Abstracts for Oral Presentation | Adult

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