Stormy Encounter with Partial Hydatidiform Mole
Abstract
We report a case of a 40-year-old multiparous woman who underwent total abdominal hysterectomy due to massive vaginal bleeding from partial molar pregnancy. Post-operatively, she developed high-grade fever, profuse sweating and shortness of breath. Examination revealed tachycardia, hypertension, elevated jugular venous pressure, crackles on both lower lung fields, with no palpable thyroid mass. Free thyroxine (FT4) and human chorionic gonadotropin β-subunit (β-hCG) were markedly elevated, while thyroid stimulating hormone (TSH) was significantly suppressed. With a Burch and Wartofsky score of 55, thyroid storm from the molar pregnancy was considered. She was given propylthiouracil (PTU), propranolol and hydrocortisone. Resolution of her signs and symptoms were noted 2 to 3 days following treatment.
Downloads
References
Lim BH, Raman S, Sivanesaratnam V, et al. Thyrotoxicosis in pregnancy-A six year review. Singapore Med J. 1989;30(6):539-41.
Lazarus JH. Hyperthyroidism during pregnancy: Etiology, diagnosis and management. Womens Health (Lond Engl). 2005;1(1):97-104. http://dx.doi.org/10.2217/17455057.1.1.97.
Garner EI, Goldstein DP, Feltmate CM, et al. Gestational trophoblastic disease. Clin Obstet Gynecol. 2007;50(1):112–22.
Palmer JR. Advances in epidemiology of gestational trophoblastic disease. J Reprod Med. 1994;39(3):155-162.
Chiniwala NU, Woolf PD, Bruno CP, et al. Thyroid storm caused by a partial hydatidiform mole. Thyroid. 2008;18(4):479-81. http://dx.doi.org/10.1089/thy.2007.0212.
Moskovitz JB, Bond MC. Molar pregnancy-induced thyroid storm. J Emerg Med. 2010;38(5)e71-6. http://dx.doi.org/10.1016/j.jemermed.2009.08.053.
Burch HB, Wartofsky L. Life-threatening thyrotoxicosis. Thyroid storm. Endocrinol Metab Clin North Am. 1993;22(2):263-77.
Loukovaara M, Pukkala E, Lehtovirta P, et al. Epidemiology of hydatidiform mole in Finland, 1975 to 2001. Eur J Gynaecol Oncol. 2005;26(2):207-8.
Cagayan MS. Changing trends in the management of gestational trophoblastic diseases in the Philippines. J Reprod Med. 2010;55(5-6):267-72.
Altman AD, Bentley B, Murray S, et al. Maternal age-related rates of gestational trophoblastic disease. Obstet Gynecol. 2008;112(2 Pt 1):244-50.
Yoshimura M, Hershman JM. Thyrotropic action of human chorionic gonadotropin. Thyroid. 1995;5(5):425-34. http://dx.doi.org/ 10.1089/thy.1995.5.425.
Yoshimura M, Hershman JM, Pang XP, et al. Activation of the thyrotropin (TSH) receptor by human chorionic gonadotropin and luteinizing hormone in Chinese hamster ovary cells expressing functional human TSH receptors. J Clin Endocrinol Metab. 1993;77(4):1009-13. http://dx.doi.org/10.1210/jcem.77.4.7691861.
Ballabio M, Poshychinda M, Ekins RP. Pregnancy-induced changes in thyroid function: Role of human chorionic gonadotropin as putative regulator of maternal thyroid. J Clin Endocrinol Metab. 1991;73(4):824-31. http://dx.doi.org/10.1210/jcem-73-4-824.
Braunstein GD, Hershman JM. Comparison of serum pituitary thyrotropin and chorionic gonadotropin concentration throughout pregnancy. J Clin Endocrinol Metab. 1976;42(6):1123-6. http://dx.doi.org/10.1210/jcem-42-6-1123.
Higgins HP, Hershman JM, Kenimer JG, et al. The thyrotoxicosis of hydatidiform mole. Ann Intern Med. 1975;83(3):307-11.
Rodbard D, Feldman Y, Jaffe ML, et al. Kinetics of two-site immunoradiometric (‘sandwich’) assays-II. Studies on the nature of the ‘high-dose hook effect’. Immunochemistry. 1978; 15(2):77-82. http://dx.doi.org/10.1016/0161-5890(78)90046-9.
Nayak B, Burman K. Thyrotoxicosis and thyroid storm. Endocrinol Metab Clin North Am. 2006;35(4):663-86, vii . http://dx.doi.org/10.1016/j.ecl.2006.09.008.
Steier JA, Bergsjø P, Myking OL. Human chorionic gonadotropin in maternal plasma after induced abortion, spontaneous abortion, and removed ectopic pregnancy. Obstet Gynecol. 1984;64(3):391-4.
Franke HR, Risse EK, Kenemans P, et al. Plasma human chorionic gonadotropin disappearance in hydatidiform mole: A central registry report from the Netherlands. Obstet Gynecol. 1983;62(4):467-73.
Cunningham FG, Leveno KJ, Bloom SL, et al. Gestational trophoblastic disease. In: A Seils, KG Edmonson, K Davis, DJ Rouse, KY Spong, editors. Williams Obstetrics. 22nd ed. New York: McGraw Hill, 2005.
Kohorn EI. The new FIGO 2000 staging and risk factor scoring system for gestational trophoblastic disease: description and critical assessment. Int J Gynecol Cancer. 2001;11(1):73-7. http://dx.doi.org/ 10.1046/j.1525-1438.2001.011001073.x.
Published
How to Cite
Issue
Section
License
Journal of the ASEAN Federation of Endocrine Societies is licensed under a Creative Commons Attribution-NonCommercial 4.0 International. (full license at this link: http://creativecommons.org/licenses/by-nc/3.0/legalcode).
To obtain permission to translate/reproduce or download articles or use images FOR COMMERCIAL REUSE/BUSINESS PURPOSES from the Journal of the ASEAN Federation of Endocrine Societies, kindly fill in the Permission Request for Use of Copyrighted Material and return as PDF file to jafes@asia.com or jafes.editor@gmail.com.
A written agreement shall be emailed to the requester should permission be granted.