Pattern of Weight Loss after Successful Enucleation of an Insulin-producing Pancreatic Neuroendocrine Tumor

Authors

  • Mark Anthony Sandoval University of the Philippines-Philippine General Hospital
  • Tom Edward Lo Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila
  • A' Ericson Berberabe Divison of Hepatobiliary and Pancreatic Surgery, Department of Surgery, College of Medicine and Philippine General Hospital, University of the Philippines Manila
  • Mark Anthony De Lusong Section of Gastroenterology, Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila
  • Juan Maria Ibarra Co Section of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Cardinal Santos Medical Center, San Juan City

Abstract

We report the case of a patient with hypoglycemic symptoms and weight gain.  Biochemical investigations revealed endogenous hyperinsulinemic hypoglycemia.  A CT scan and MRI of the abdomen were initially not successful in localizing a pancreatic mass.  However, an endoscopic ultrasound was able to demonstrate a pancreatic head mass.  Enucleation of the mass resulted in clinical and biochemical improvement.  This report also demonstrates the pattern of weight loss after surgery, showing an initial phase of gradual weight loss followed by a rapid loss of weight.  This pattern of weight loss after successful removal of an insulin-producing pancreatic neuroendocrine tumor is a novel addition to the existing knowledge we have about this condition.

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References

Klimstra DS, Modlin IR, Coppola D, Lloyd RV and Suster S. The pathologic classification of neuroendocrine tumors. Pancreas. 2010;39(6):707-712.

Vaidakis D, Karoubalis J, Papa T, Pladitis G and Zografos GN. Pancreatic insulinoma: Current issues and trends. Hepatobiliary and Pancreatic Diseases International. 2010; 9:234-241.

Pongprasobchai S, Lertwattanarak R, Pausawasdi N, Prachayakul V. Diagnosis and localization of insulinoma in Thai patients: Performance of endoscopic ultrasonography compared to computed tomography and magnetic resonance imaging. J Med Assoc Thai. 2013 Feb;96(Suppl 2):S187-93.

Kaltsas GA, Besser GM, Grossman AB. The diagnosis and medical management of advanced neuroendocrine tumors. Endocrine Reviews. 2004;25(3):458-511. http://dx.doi.org/10.1210/er.2003-0014.

Madathil A and Weaver J. Insulinoma presenting as postprandial hypoglycaemia. BMJ Case Reports. 2011. http://dx.doi.org/10.1136/bcr.07.2011.4477.

Lemoncito MV, Josol CV, Ramos HC, Quimpo JA, Lantion-Ang FL, Guazon MLV. Recurrent hyperinsulinemic hypoglycemia in a 23-year old male with negative imaging studies: An enigma of insulinoma. Philipp J Intern Med. 2011;49(3):177-184.

Tsang YP, Lang BH, Shek TW. Assessing the short- and long-term outcomes after resection of benign insulinoma. ANZ Journal of Surgery 2014 Oct 23. doi: 10.1111/ans.12891.

Published

2015-11-30

How to Cite

Sandoval, M. A., Lo, T. E., Berberabe, A. E., De Lusong, M. A., & Co, J. M. I. (2015). Pattern of Weight Loss after Successful Enucleation of an Insulin-producing Pancreatic Neuroendocrine Tumor. Journal of the ASEAN Federation of Endocrine Societies, 30(2), 159. Retrieved from https://www.asean-endocrinejournal.org/index.php/JAFES/article/view/178

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Section

Case Reports

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