Meningitis and CSF Rhinorrhea as Initial Presentations of Untreated Macroprolactinoma

Authors

  • Li Yunkai Andrew Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore
  • Mavis Ang Kexin Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore
  • Seow Cherng Jye Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore
  • Lee Kim En Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore

Abstract

Macroprolactinomas often present with hyperprolactinemia or space-occupying symptoms. There are few case reports of macroprolactinomas presenting as meningitis and CSF rhinorrhea. Presented is a case of a 51-year-old Chinese male who presented with meningitis and pneumonia, and thereafter, developed rhinorrhea. Magnetic Resonance Imaging of the brain revealed a macroprolactinoma. He subsequently underwent a trans-sphenoidal hypophysectomy to remove the tumor.

Downloads

Download data is not yet available.

References

Klibanski A. Prolactinomas. N Engl J Med. 2010; 362:1219-1226.

Strebel PM, Zacur HA, Gold EB. Headache, hyperprolactinemia, and prolactinomas. Obstet Gynecol. 1986 Aug; 68(2):195-199.

Suliman S.G.I., Gurlek A, Byrne J.V., et al. Nonsurgical Cerebrospinal Fluid Rhinorrhea in Invasive Macroprolactinoma: Incidence, Radiological and Clinicopathological features. J. Clin. Endocrinol. Metab. 2007; 92:3829-3835.

Cole I E. Cerebrospinal fluid rhinorrhea in pituitary tumours. J R Soc Med. 1980 April; 73(4):244-254.

Obana WG, Hodes JE, Weinstein PR, Wilson CB. Cerebrospinal fluid rhinorrhea in patients with untreated pituitary adenoma: Report of two cases. Surg Neurol. 1990; 33:336-340

Honegger J, Psaras T, Petrick M, Reincke M. Meningitis as a presentation of macroprolactinoma. Exp Clin Endocrinol Diabetes. 2009; 117:361-364

Ohtakara K, Matsubara T, Kojima T, Taki W, Wara S. Cerebrospinal fluid rhinorrhea associated with untreated prolactinoma: Case report. Neurol Med Chir (Tokyo). 2000; 40:413-418.

Downloads

Published

2014-05-28

How to Cite

Andrew, L. Y., Kexin, M. A., Cherng Jye, S., & Kim En, L. (2014). Meningitis and CSF Rhinorrhea as Initial Presentations of Untreated Macroprolactinoma. Journal of the ASEAN Federation of Endocrine Societies, 26(2), 173. Retrieved from https://www.asean-endocrinejournal.org/index.php/JAFES/article/view/92

Issue

Vol. 26 No. 2 (2011): November Issue

Section

Case Reports

License

Journal of the ASEAN Federation of Endocrine Societies is licensed under a Creative Commons Attribution-NonCommercial 4.0 International. (full license at this link: http://creativecommons.org/licenses/by-nc/3.0/legalcode).

To obtain permission to translate/reproduce or download articles or use images FOR COMMERCIAL REUSE/BUSINESS PURPOSES from the Journal of the ASEAN Federation of Endocrine Societies, kindly fill in the Permission Request for Use of Copyrighted Material and return as PDF file to jafes@asia.com or jafes.editor@gmail.com.

A written agreement shall be emailed to the requester should permission be granted.