@article{Ferwani_Maldar_Shah_Chauhan_Chadha_2022, title={Prevalence of Bacterial Urinary Tract Infection Among Patients With Type 2 Diabetes Mellitus on Sodium-Glucose Cotransporter-2 Inhibitors: A Prospective Real-World Setting Study}, volume={37}, url={https://asean-endocrinejournal.org/index.php/JAFES/article/view/1305}, DOI={10.15605/jafes.037.02.04}, abstractNote={<p><strong>Background</strong>. Genitourinary tract infections, mycotic as well as bacterial, as defined by clinical symptoms, are one of the common adverse effects associated with the use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in type 2 diabetes mellitus (T2DM) patients in clinical trials. However, Indian data in terms of the prevalence of culture-proven bacterial type of urinary tract infection (UTI), and the causative organism is limited.</p> <p><strong>Objective.</strong> This study aimed to determine the prevalence and causative agents of bacterial UTI among patients with T2DM on SGLT2i.</p> <p><strong>Methodology.</strong> This was a prospective longitudinal study involving all patients with T2DM who were prescribed with SGLT2i, uncontrolled on other oral anti-diabetic medications, from June 2019 to February 2020. Prevalence of bacterial UTI was evaluated at baseline and 12 weeks after initiation of SGLT2i.</p> <p><strong>Results</strong>. A total of 80 patients were started on SGLT2i. One female patient on canagliflozin had significant asymptomatic bacteriuria and the causative agent was <em>Acinetobacter baumannii</em>. One male patient on dapagliflozin had symptomatic urinary tract infection with negative urine culture study. Four patients developed genital mycotic infection.</p> <p><strong>Conclusion</strong>. In this real-world study, SGLT2i as a class, was well tolerated with favorable safety profile, and risk of developing significant bacteriuria and/or symptomatic UTI was minimal.</p>}, number={2}, journal={Journal of the ASEAN Federation of Endocrine Societies}, author={Ferwani, Pankaj and Maldar, Aasim and Shah, Nishitkumar and Chauhan, Phulrenu and Chadha, Manoj}, year={2022}, month={Jul.}, pages={5–8} }