@article{Mohamed_Lim_Mumtaz_Uppal_Mukherjee_Kassim_Sreedharan_Doraiswamy_Chong_Tat_Nordin_Lau Hui Giek_Hussein_Kadir_Lau_Chan_2023, title={Initiating or Switching to Insulin Degludec/Insulin Aspart in Adults with Type 2 Diabetes in Malaysia: Results from a Prospective, Non-Interventional Real-World Study}, volume={38}, url={https://asean-endocrinejournal.org/index.php/JAFES/article/view/2461}, DOI={10.15605/jafes.038.01.12}, abstractNote={<p><strong>Objectives.</strong> Insulin degludec (IDeg)/insulin aspart (IAsp; IDegAsp) is a co-formulation of 70% IDeg and 30% IAsp. According to several randomized controlled trials, IDegAsp is effective and safe for patients with type 2 diabetes mellitus (T2DM). A subgroup analysis of the ARISE study was conducted to explore the safety and efficacy of IDegAsp among Malaysian patients with T2DM in real-world settings.</p> <p><strong>Methodology.</strong> ARISE, an open-label, multicenter, non-interventional, prospective study was conducted between August 2019 and December 2020. Adult Malaysian patients with T2DM who were enrolled from 14 sites received IDegAsp as per the local label for 26 weeks. The primary endpoint was change in glycated hemoglobin (HbA1c) levels from baseline<br />to end of study (EOS).</p> <p><strong>Results.</strong> Of the 182 patients included in the full analysis set, 159 (87.4%) completed the study. From baseline to EOS, HbA1c (estimated difference [ED]: –1.3% [95% CI: –1.61 to –0.90]) and fasting plasma glucose levels (ED: –1.8 mmol/L [95% CI: –2.49 to –1.13]) were significantly reduced (p<0.0001). The patient-reported reduced hypoglycemic episodes (overall and nocturnal) during treatment. Overall, 37 adverse events were observed in 23 (12.6%) patients.</p> <p><strong>Conclusion.</strong> Switching or initiating IDegAsp treatment resulted in significant improvements in glycemic control and a reduction in hypoglycemic episodes.</p>}, number={1}, journal={Journal of the ASEAN Federation of Endocrine Societies}, author={Mohamed, Mafauzy and Lim , Siang Chin and Mumtaz, Malik and Uppal, Shweta and Mukherjee, Deepak and Kassim, Mohamed Saiful Mohd and Sreedharan, Shalini and Doraiswamy, Amudha Murugan and Chong, Kuck Meng and Tat, Lu Yu and Nordin, Sudzilla Binti and Lau Hui Giek, Jeshen and Hussein, Zanariah and Kadir, Khalid Abdul and Lau, Bik Kui and Chan, Siew Pheng}, year={2023}, month={Jan.}, pages={37–44} }