@article{Phyu_Hlain_Zaw_Htway_Sein_2020, title={Correlation Study Between Erythrocyte Acetylcholinesterase Activity, Serum Malondialdehyde and Insulin Sensitivity in Agricultural Workers and Non-agricultural Workers in Nat-Kan Village, Magway Township}, volume={35}, url={https://asean-endocrinejournal.org/index.php/JAFES/article/view/645}, DOI={10.15605/jafes.035.01.14}, abstractNote={<p><strong>Objective.</strong> This study determined the correlation between erythrocyte acetylcholinesterase (AChE) activity, serum malondialdehyde (MDA) and insulin sensitivity in agricultural workers and non-agricultural workers.</p> <p><strong>Methodology.</strong> The cross-sectional comparative study was undertaken in 45 agricultural and 45 non-agricultural workers from Nat-Kan Village, Magway Township. Erythrocyte acetylcholinesterase activity and serum malondialdehyde were measured by spectrophotometric method. Insulin sensitivity was calculated by homeostasis model assessment (HOMA-IR).</p> <p><strong>Results.</strong> Mean erythrocyte AChE activity was significantly lower in agricultural (3553.99 IU/L) compared with nonagricultural workers (4432.68 IU/L) (<em>p</em><0.001). A significant high level of mean serum MDA was observed in agricultural workers (0.74 versus 0.28 μmol/L, <em>p</em><0.001). Median HOMA-IR value was significantly higher in agricultural (2.74) than that of non-agricultural workers (2.28) (p<0.05). The risk of insulin resistance was 2.8 times greater in agricultural workers than non-agricultural workers (OR 2.8, 95% CI, 1.18 to 6.72). Erythrocyte AChE activity had weak negative correlation with serum MDA level (r=-0.357, p<0.001) and HOMA-IR (ρ= 0.305, <em>p</em><0.05). There was a significant but weak positive correlation between serum MDA level and HOMA-IR (ρ=0.355, <em>p</em><0.001).</p> <p><strong>Conclusion.</strong> Organophosphate pesticide exposure lowered erythrocyte AChE activity and increased oxidative stress. Oxidative stress is partly attributed to the development of insulin resistance.</p>}, number={1}, journal={Journal of the ASEAN Federation of Endocrine Societies}, author={Phyu, Mya Pwint and Hlain, Zarchi Theint Theint and Zaw, Thurein and Htway, Soe Minn and Sein, Mya Thanda}, year={2020}, month={May}, pages={85–92} }