@article{Anuar Zaini_Tung_Bahuri_Jalaludin_2020, title={Congenital Hypothyroidism in Children: A Cross-Sectional Study in a Tertiary Centre in Malaysia}, volume={35}, url={https://asean-endocrinejournal.org/index.php/JAFES/article/view/721}, DOI={10.15605/jafes.035.01.11}, abstractNote={<center><strong><img src="https://asean-endocrinejournal.org/public/site/images/admin/va-31-md.jpg" alt="" width="618" height="309"></strong></center><center><img src="https://asean-endocrinejournal.org/public/site/images/admin/va-31-lay.jpg" alt="" width="618" height="309"></center><center><em>*Visual Abstracts prepared by Dr. Carmen Carina Cabrera</em></center> <p><strong>Introduction.</strong> The causes of congenital hypothyroidism (CHT) are thyroid dysgenesis (TD), dyshormonogenesis (TDH)or transient (TH).</p> <p><strong>Methodology.</strong> This is a cross-sectional study looking at data over a period of 16 years (2000-2016). Confirmed cases had thyroid scan at the age of 3-years-old and repeated TFT (after 6 weeks off medications). Relevant data was collected retrospectively.</p> <p><strong>Results.</strong> Forty (60% female) children with CHT were included in the study. Thirty (75%) children presented with high cord TSH. Nine (23%) presented after 2 weeks of life. Majority were diagnosed with TDH (42.5%) with TD and TH of 40% and 17.5% respectively. Median cord TSH of children with TD was significantly higher compared to TDH and TH (<em>p=</em>0.028 and <em>p=</em>0.001 respectively). L-thyroxine doses were not significantly different between TD, TDH and TH at diagnosis or at 3 years.</p> <p><strong>Conclusions.</strong> TDH is highly prevalent in our population. TD may present after 2 weeks of life. One in five children treated for CHT had TH. Differentiating TD, TDH and TH before initiating treatment remains a challenge in Malaysia. This study provides clinicians practical information needed to understand the possible aetiologies from a patient’s clinical presentation, biochemical markers and treatment regime. Reassessing TH cases may be warranted to prevent<br>unnecessary treatment.</p>}, number={1}, journal={Journal of the ASEAN Federation of Endocrine Societies}, author={Anuar Zaini, Azriyanti and Tung, Yu Feng and Bahuri, Nor Faizal Ahmad and Jalaludin, Muhammad Yazid}, year={2020}, month={Apr.}, pages={62–67} }