@article{Theint_Khin_Thein_Sein_2020, title={Relationship between Plasma Adiponectin Level and Corrected QT interval in Smoker and Non-Smoker Adult Male Subjects}, volume={35}, url={https://asean-endocrinejournal.org/index.php/JAFES/article/view/861}, DOI={10.15605/jafes.035.02.09}, abstractNote={<p><strong>Objective.</strong> This study determined the relationship between plasma adiponectin level and corrected QT interval (QTc) in smokers and non-smokers.</p> <p><strong>Methodology.</strong> This cross-sectional analytical study was undertaken in 30 smokers and 30 non-smokers. Plasma<br>adiponectin level was determined by enzyme-linked immunosorbent assay (ELISA). The QT interval was measured by routine 12-lead ECG with Lead II rhythm and QTc was calculated.</p> <p><strong>Results.</strong> Mean plasma adiponectin level was significantly lower in smokers (27.89±15 μg/ml) than that of non-smokers (52.13±21.57μg/ml) (p<0.001). Mean QTc interval was significantly longer in smokers than that of non-smokers (415.37±29.9 versus 395.63±26.13 ms, <em>p</em><0.01). Higher risk of low adiponectin level (odds ratio [OR],8.1; 95% confidence interval [CI],1.61-40.77) and QTc interval prolongation (OR,6; 95%CI,1.17-30.73) were observed in smokers. There was weak significant negative correlation between plasma adiponectin level and QTc interval in the study population (n=60, r=-0.407, <em>p</em>=0.001). Moreover, low plasma adiponectin level was significantly associated with prolonged QTc interval in the study population (n=60, Fisher’s exact <em>p value</em><0.05). Risk of QTc interval prolongation was 4.3 times higher in subjects with low plasma adiponectin level (OR,4.27; 95% CI,1.05-17.46).</p> <p><strong>Conclusion.</strong> Smokers have greater risk for low plasma adiponectin level and prolonged QTc interval. There is a relationship between plasma adiponectin level and QTc interval.</p>}, number={2}, journal={Journal of the ASEAN Federation of Endocrine Societies}, author={Theint, Yin Thu and Khin, Ei Ei and Thein, Ohnmar Myint and Sein, Mya Thanda}, year={2020}, month={Oct.}, pages={190–195} }