TY - JOUR AU - Enverga, Mariel AU - Isidro, Maria Jocelyn AU - Ang-Golangco, Nerissa PY - 2022/12/09 Y2 - 2024/03/28 TI - The Association Between Serum 25-hydroxyvitamin D and Glycemic Control in Patients With Diabetes Mellitus: A Single-Center Retrospective Study JF - Journal of the ASEAN Federation of Endocrine Societies JA - J ASEAN Fed Endocr Soc VL - 38 IS - 1 SE - Original Articles DO - 10.15605/jafes.038.01.04 UR - https://asean-endocrinejournal.org/index.php/JAFES/article/view/1919 SP - 13-20 AB - <p><span style="font-weight: bolder;">Objective. </span>To determine the association between serum 25-hydroxyvitamin D (25(OH)D) and measures of glycemic control, hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG), in adult patients with diabetes mellitus.</p><p><strong>Methodology.</strong> This is an analytical cross-sectional study of 270 patients with diabetes admitted to a tertiary hospital. Serum 25(OH)D levels were categorized as follows: sufficient (&gt;30 ng/mL), insufficient (20 to 30 ng/mL), and deficient (&lt;20 ng/mL). The correlation of HbA1c and FPG with serum 25(OH)D and other variables was determined using Spearman’s rho (ρ) coefficient. The risk factors associated with HbA1c ≥7% and FPG ≥126 mg/dL were determined using logistic regression analysis to generate crude and adjusted odds ratios. The null hypothesis was rejected at 0.05 α-level of significance.</p><p><strong>Results.</strong> The median serum 25(OH)D was 18.92 (range 3.56–56.3) ng/mL. Ninety percent (245 patients) had vitamin D levels below 30 ng/mL. This study showed that vitamin D level is significantly but weakly correlated with patient’s age (ρ=0.339) and duration of diabetes (ρ=0.147), whereas it had inverse correlations with BMI (ρ=-0.134), HbA1c (ρ=-0.261), and FPG (ρ=-0.198).</p><p><strong>Conclusion.</strong> In this study, we found a possible association between vitamin D levels and measures of glycemic control among this group of adult Filipino patients with diabetes mellitus, but further investigations in other cohorts of individuals with diabetes are needed.</p> ER -