TY - JOUR AU - Theint, Yin Thu AU - Khin, Ei Ei AU - Thein, Ohnmar Myint AU - Sein, Mya Thanda PY - 2020/10/19 Y2 - 2024/03/29 TI - Relationship between Plasma Adiponectin Level and Corrected QT interval in Smoker and Non-Smoker Adult Male Subjects JF - Journal of the ASEAN Federation of Endocrine Societies JA - J ASEAN Fed Endocr Soc VL - 35 IS - 2 SE - Original Articles DO - 10.15605/jafes.035.02.09 UR - https://asean-endocrinejournal.org/index.php/JAFES/article/view/861 SP - 190-195 AB - <p><strong>Objective.</strong> This study determined the relationship between plasma adiponectin level and corrected QT interval (QTc) in smokers and non-smokers.</p><p><strong>Methodology.</strong> This cross-sectional analytical study was undertaken in 30 smokers and 30 non-smokers. Plasma<br>adiponectin level was determined by enzyme-linked immunosorbent assay (ELISA). The QT interval was measured by routine 12-lead ECG with Lead II rhythm and QTc was calculated.</p><p><strong>Results.</strong> Mean plasma adiponectin level was significantly lower in smokers (27.89±15 μg/ml) than that of non-smokers (52.13±21.57μg/ml) (p&lt;0.001). Mean QTc interval was significantly longer in smokers than that of non-smokers (415.37±29.9 versus 395.63±26.13 ms, <em>p</em>&lt;0.01). Higher risk of low adiponectin level (odds ratio [OR],8.1; 95% confidence interval [CI],1.61-40.77) and QTc interval prolongation (OR,6; 95%CI,1.17-30.73) were observed in smokers. There was weak significant negative correlation between plasma adiponectin level and QTc interval in the study population (n=60, r=-0.407, <em>p</em>=0.001). Moreover, low plasma adiponectin level was significantly associated with prolonged QTc interval in the study population (n=60, Fisher's exact <em>p value</em>&lt;0.05). Risk of QTc interval prolongation was 4.3 times higher in subjects with low plasma adiponectin level (OR,4.27; 95% CI,1.05-17.46).</p><p><strong>Conclusion.</strong> Smokers have greater risk for low plasma adiponectin level and prolonged QTc interval. There is a relationship between plasma adiponectin level and QTc interval.</p> ER -