Successful Oral Levothyroxine Desensitization in a Patient with Severe Hypothyroidism Post Radioactive Iodine Therapy: A Case Report

Yi Jiang Chua; Bay Shing Shen; Taye Zhi Yun; Carolina Singarayar; Foo Siew Hui

doi:10.15605/jafes.036.02.10

Authors

Yi Jiang Chua Selayang Hospital, Selangor, Malaysia https://orcid.org/0000-0001-9388-747X
Bay Shing Shen Selayang Hospital, Selangor, Malaysia https://orcid.org/0000-0003-2315-6676
Taye Zhi Yun Selayang Hospital, Selangor, Malaysia
Carolina Singarayar Selayang Hospital, Selangor, Malaysia
Foo Siew Hui Selayang Hospital, Selangor, Malaysia

DOI:

https://doi.org/10.15605/jafes.036.02.10

Keywords:

levothyroxine, thypersensitivity, hypothyroidism, desensitization

Abstract

Levothyroxine remains the standard therapy for patients with hypothyroidism worldwide. Levothyroxine allergy is rarely seen and alternative therapies are less efficacious and scarcely available. The use of liothyronine (LT3) monotherapy is less favoured due to its short half-life and unpredictable pharmacological profile. We report a 59-year-old male with a hypersensitivity reaction to levothyroxine who was successfully desensitized with oral levothyroxine within a day using a 14-step protocol (Table 1.1).

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Author Biographies

Yi Jiang Chua, Selayang Hospital, Selangor, Malaysia

Medical Physician, Endocrinology Fellow

Endocrinology Unit, Department of Medicine

Bay Shing Shen, Selayang Hospital, Selangor, Malaysia

Medical Officer, Endocrinology Unit, Department of Medicine

Taye Zhi Yun, Selayang Hospital, Selangor, Malaysia

Clinical Pharmacist, Pharmacy Department

Carolina Singarayar, Selayang Hospital, Selangor, Malaysia

Endocrinologist, Endocrinology Unit, Department of Medicine

Foo Siew Hui, Selayang Hospital, Selangor, Malaysia

Senior Consultant, Endocrinologist

Endocrinology Unit, Department of Medicine

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