Pediatric Adrenocortical Oncocytoma presenting as Cushing’s Syndrome and Peripheral Precocious Puberty

A Case Report and Review of Literature

  • Niya Narayanan Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India https://orcid.org/0000-0001-8403-7756
  • Sadishkumar Kamalanathan Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India https://orcid.org/0000-0002-2371-0625
  • Jayaprakash Sahoo Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
  • Dukhabandhu Naik Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India https://orcid.org/0000-0003-4568-877X
  • Sambandan Kumaravel Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India https://orcid.org/0000-0002-1239-5180
  • Rajesh Nachiappa Ganesh Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
Keywords: adrenal oncocytoma, functioning adrenal adenoma, pediatric adrenal tumours

Abstract

Oncocytic adrenocortical tumours (OATs) or oncocytomas are extremely rare and are usually benign and nonfunctional. We report the case of a 4-year old male with a right-sided, functional oncocytic adrenocortical adenoma, who presented with precocious puberty and Cushing’s syndrome. After work-up, the patient underwent laparoscopic adrenalectomy. The excised adrenal mass weighed 21 g and measured 3.5 cm in maximum dimension. Histological examination demonstrated no features suggestive of aggressive biological behaviour. The patient had no features of recurrent or metastatic disease and had prepubertal testosterone levels with suppressed hypothalamic-pituitary-adrenal axis twelve months after the surgery. A discussion of this case and a review of the literature on functional OATs in the pediatric population are presented.

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Author Biographies

Niya Narayanan, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Department of Endocrinology

Sadishkumar Kamalanathan, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Professor, Department of Endocrinology

Jayaprakash Sahoo, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Professor, Department of Endocrinology

Dukhabandhu Naik, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Professor, Department of Endocrinology

Sambandan Kumaravel , Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Department of Pediatric Surgery

Rajesh Nachiappa Ganesh, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Department of Pathology

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Published
2021-10-06
How to Cite
Narayanan, N., Kamalanathan, S., Sahoo, J., Naik, D., Kumaravel , S., & Nachiappa Ganesh, R. (2021). Pediatric Adrenocortical Oncocytoma presenting as Cushing’s Syndrome and Peripheral Precocious Puberty: A Case Report and Review of Literature. Journal of the ASEAN Federation of Endocrine Societies, 36(2). https://doi.org/10.15605/jafes.036.02.17
Section
Case Reports