Lower Plasma Selenoprotein P Levels in Regularly Exercising Young Adults

Main Article Content

Swe Mar Oo
Min Thar Htut
Ye Win Htun
Aye Aye Mon
May Pyone Kyaw


Objective. Physical exercise can provide many health benefits in humans. Exercise-induced reactive oxygen species (ROS) formation and its downstream signaling cascades are reported to induce mitochondrial biogenesis in exercising tissues. Selenoprotein P (SELENOP) is the antioxidant hepatokine, whose hypersecretion is associated with various metabolic diseases.  It was reported to impair exercise-induced reactive oxygen species signaling and inhibit subsequent mitochondrial biogenesis in mice. However, the relationship between selenoprotein P and mitochondrial dynamic in humans has not yet been reported. While reduction of plasma selenoprotein P becomes an attractive therapeutic target for metabolic diseases, the role of regular exercise in this regard is still unknown. This study aimed to analyze the influence of regular habitual exercise on plasma selenoprotein P levels and its association with leucocyte mitochondrial DNA copy number in healthy young adults.

Methodology. Plasma selenoprotein P levels and leucocyte mitochondrial DNA copy numbers were compared in 44 regularly exercising subjects and 44 non-exercising controls, and the correlation between the two parameters was analyzed. Plasma selenoprotein P levels were measured by Enzyme-linked Immunosorbent Assay, and leucocyte mitochondrial DNA copy numbers were measured using the qPCR method.

Results. The regular-exercise group had lower plasma selenoprotein P levels with higher leucocyte mitochondrial DNA copy numbers than the non-exercise group. There was a tendency of negative correlation between the two variables in our studied population. 

Conclusion. Regular habitual exercise has a beneficial effect on reducing plasma selenoprotein P levels while raising mitochondrial DNA copy numbers.


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How to Cite
Swe Mar Oo, Min Thar Htut, Ye Win Htun, Aye Aye Mon, & May Pyone Kyaw. (2022). Lower Plasma Selenoprotein P Levels in Regularly Exercising Young Adults. Journal of the ASEAN Federation of Endocrine Societies. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/1217
Original Articles
Author Biographies

Swe Mar Oo, University of Medicine Taunggyi, Myanmar

Department of Biochemistry

Min Thar Htut, University of Medicine 2, Yangon, Myanmar

Department of Biochemistry

Ye Win Htun, University of Medicine 2, Yangon, Myanmar

Department of Biochemistry

May Pyone Kyaw, University of Medicine 2, Yangon, Myanmar

Department of Biochemistry


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