Effect of Cholecalciferol on GLUT4 Expression in Adipocyte of Diabetic Rats

Authors

  • Dewi Ratna Sari Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java
  • Rimbun - Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java
  • Tri Hartini Yuliawati Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java
  • Joni Susanto Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java
  • Ari Gunawan Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java
  • JM Harjanto Department of Physiology, Faculty of Medicine, Universitas Airlangga

Abstract

This research was conducted to examine the effect of cholecalciferol on fasting blood glucose (FBG), adipocyte diameter and glucose transporter (GLUT) 4 expression in adipocytes of diabetic rats. Nineteen male Wistar strain diabetic rats were divided into 4 groups (K, X1, X2 and X3). Cholecalciferol was administered in the amount of 6.25 μg/kg in X1, 12.5 μg/kg in X2 and 25 μg/kg in X3 per orem, once daily for 14 days. Group K received the placebo. There were no significant differences in FBG (p=0.199) and adipocyte diameter (p=0.218) between groups but there were significant differences in the expression of GLUT4 between control and treatment groups. Thus, cholecalciferol can increase GLUT4 expression in adipocyte without altering FBG and adipocyte diameter of diabetic rats.

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References

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Published

2015-11-30

How to Cite

Sari, D. R., -, R., Yuliawati, T. H., Susanto, J., Gunawan, A., & Harjanto, J. (2015). Effect of Cholecalciferol on GLUT4 Expression in Adipocyte of Diabetic Rats. Journal of the ASEAN Federation of Endocrine Societies, 30(2), 187. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/197

Issue

Vol. 30 No. 2 (2015): November Issue

Section

Brief Communications

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