Infundibuloneurohypophysitis as a Cause of Central Diabetes Insipidus in an Indian Woman Two Years Postpartum

  • Sueziani Zainudin Department of Endocrinology, Singapore General Hospital
  • Tey Beng Hea Department of Medicine, Alexandra Hospital, Singapore
  • Jean-Pierre Laporte Department of Diagnostic Radiology, Khoo Teck Puat Hospital, Singapore
  • Sum Chee Fang Department of Medicine, Khoo Teck Puat Hospital, Singapore


Infundibuloneurohypophysitis is a rare disorder which involves inflammation of the pituitary stalk and posterior pituitary gland. We describe the case of a woman in her late postpartum period presenting with acute onset central diabetes insipidus. Magnetic resonance imaging (MRI) showed nodular enhancement of the pituitary infundibulum and ectopia of the posterior pituitary gland. The treatment was hormone replacement. The role of steroid therapy for this condition is controversial.


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Panicker HK, Janicic N, Nguyen D et al. Presumed infundibuloneurohypophysitis: Unusual presentation in a postpartum patient. Am J Neuroradiol 2005;26(2):357-9.

Hashimoto K, Asaba K, Tamura K et al. A case of lymphocytic infundibuloneuro-hypophysitis associated with systemic lupus erythematosus. Endocr J 2002;49(6):605-10.

Crock PA. Cytosolic autoantigens in lymphocytic hypophysitis. J Clin Endocrinol Metab 1998;83(2):609-18.

Yamamoto M, Murakami Y, Nishiki M et al. A case of autoimmune hypophysitis associated with Graves’ disease. Endocr J 2002;49(6):583-7.

Caturegli P, Newschaffer C, Olivi A et al. Autoimmune hypophysitis. Endocr Rev 2005;26(5):599-614.

Colao A, Tavares LB, Pivonello R et al. “Autoimmunity and the Pituitary Gland.” In Endocrine Manifestations of Systemic Autoimmune Diseases: Handbook of Systemic Autoimmune Disease, edited by Sara E Walker and Luis J Jara. Elsevier, 2008;83-93.

Brooks BS, Gammal TE, Allison JD et al. Frequency and variation of the posterior pituitary bright signal on MR images. Am J Roentgenol 1989;153(5):1033-8.

Rivera JA. Lymphocytic hypophysitis: Disease spectrum and approach to diagnosis and therapy. Pituitary 2006;9(1):35-45.

Elster AD. Modern imaging of the pituitary. Radiology 1993;187(1):1-14.

Katzman GL, Langford CA, Sneller CM et al. Pituitary involvement by Wegener's granulomatosis: A report of two cases. Am J Neuroradiol 1999;20(3):519-23.

Imura H, Nakao K, Shimatsu A et al. Lymphocytic infundibuloneurohypophysitis as a cause of central diabetes insipidus. N Engl J Med 1993;329(10):683-9.

Vasile M, Marsot-Dupuch K, Kujas M et al. Idiopathic granulomatous hypophysitis: Clinical and imaging features. Neuroradiol 1997;39(1):7-11.

Singh S. Pituitary tuberculoma: Magnetic resonance imaging. Neurol India 2003;51(4): 548-50.

Kristof RA, Van Roost D, Klingmüller D et al. Lymphocytic hypophysitis: Non-invasive diagnosis and treatment by high dose methylprednisolone pulse therapy? J Neurol Neurosurg Psychiatry 1999;67(3):398-402.

Molitch ME, Gillam MP. Lymphocytic hypophysitis. Hormone Res 2007; 68(Suppl 5):145-50.

How to Cite
Zainudin, S., Hea, T. B., Laporte, J.-P., & Fang, S. C. (2014). Infundibuloneurohypophysitis as a Cause of Central Diabetes Insipidus in an Indian Woman Two Years Postpartum. Journal of the ASEAN Federation of Endocrine Societies, 27(1), 100. Retrieved from
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