The Prevalence of Advanced Liver Fibrosis among Patients with Type 2 Diabetes Mellitus

A Single-Centre Experience in Penang, Malaysia

Authors

  • Xe Hui Lee Penang General Hospital, Penang, Malaysia https://orcid.org/0000-0002-9976-7505
  • Lisa Mohamed Nor Putrajaya Hospital, Wilayah Persekutuan Putrajaya, Malaysia
  • Choon Seong Ang Penang General Hospital, Penang, Malaysia
  • Toh Peng Yeow Penang General Hospital, Penang, Malaysia
  • Shueh Lin Lim Penang General Hospital, Penang, Malaysia https://orcid.org/0000-0003-0369-1954

DOI:

https://doi.org/10.15605/jafes.038.01.08

Keywords:

type 2 diabetes mellitus, Non-alcoholic Fatty Liver disease, Advanced Liver Fibrosis, transient elastography, FIB-4 Index

Abstract

Objectives. This study aimed to compare the severity of COVID-19, inflammatory parameters and clinical outcomes
among patients with normal and subnormal levels of Vitamin D.

Methodology. This is a retrospective cohort study of 135 patients admitted in a tertiary hospital for COVID-19. Patients
were grouped according to their Vitamin D level. Primary outcome measure was the composite of all-cause mortality and
morbidity. Other outcome measures determined were the comparison among the groups on the severity of COVID-19
infection, changes in inflammatory parameters, length of hospital stay and duration of respiratory support.

Results. There was a significant trend of higher ICU admission, mortality (p-value= 0.006) and poor clinical outcome
(p-value=0.009) among the Vitamin D deficient group. No significant difference was found for most of the inflammatory
parameters, duration of hospital stay and respiratory support. Overall, patients with deficient, but not insufficient Vitamin
D level had 6 times higher odds of composite poor outcome than those with normal Vitamin D (crude OR=5.18, p-value=
0.003; adjusted OR =6.3, p-value=0.043).

Conclusion. The inverse relationship between Vitamin D level and poor composite outcome observed in our study
suggests that low Vitamin D may be a risk factor for poor prognosis among patients admitted for COVID-19.

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Author Biographies

Xe Hui Lee, Penang General Hospital, Penang, Malaysia

Consultant Endocrinologist, Endocrinology Unit, Department of Medicine

Lisa Mohamed Nor, Putrajaya Hospital, Wilayah Persekutuan Putrajaya, Malaysia

Research Medical Officer, Clinical Research Centre

Choon Seong Ang, Penang General Hospital, Penang, Malaysia

Research Medical Officer, Clinical Research Centre

Toh Peng Yeow, Penang General Hospital, Penang, Malaysia

Senior Consultant Endocrinologist, Department of Medicine

Shueh Lin Lim, Penang General Hospital, Penang, Malaysia

Senior Consultant Endorinologist, Endocrinology Unit

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Published

2023-02-25

How to Cite

Lee, X. H., Nor, L. M., Ang, C. S., Yeow, T. P., & Lim, S. L. (2023). The Prevalence of Advanced Liver Fibrosis among Patients with Type 2 Diabetes Mellitus: A Single-Centre Experience in Penang, Malaysia. Journal of the ASEAN Federation of Endocrine Societies, 38(1), 52–61. https://doi.org/10.15605/jafes.038.01.08

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Original Articles