Primary Hyperparathyroidism from Parathyroid Carcinoma Presenting with Multiple Skeletal Fractures and Brown Cell Tumors



hypercalcemia, hyperparathyroidism, parathyroid carcinoma


We report the case of a 19-year old Filipino woman who presented with hard masses on the left upper arm and leg with multiple fractures on all extremities. Her serum calcium and intact parathyroid hormone (iPTH) levels were elevated, while serum phosphorus was low. Ultrasonography of the neck revealed a left inferior parathyroid mass. Ultrasound-guided fine needle aspiration of the mass revealed findings consistent with parathyroid carcinoma. After hydration and administration of diuretic and bisphosphonate to control the severe hypercalcemia, she subsequently underwent 3½ gland parathyroidectomy with en-bloc left thyroid lobectomy. There was immediate normalization of biochemical indices after surgery. Three months later, the fractures on all extremities were fully resolved.


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Author Biography

Jerome Barrera, Zamboanga City Medical Center

Training Officer, Department of Internal Medicine, Zamboanga City Medical Center

Chair, Research Committee Technical Review Board, Zamboanga City Medical Center

Program Head, Zamboanga Doctors' Hospital Wellness Center

Accreditor, Residency Training Program, Philippine College of Physician



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How to Cite

Esplana, C. C., & Barrera, J. (2015). Primary Hyperparathyroidism from Parathyroid Carcinoma Presenting with Multiple Skeletal Fractures and Brown Cell Tumors. Journal of the ASEAN Federation of Endocrine Societies, 30(2), 175. Retrieved from



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