Sex Reversal Syndrome (SRS): A Case of SRY-Positive 46,XX Testicular Disorder

Kishore Kumar shil; Tahmina  Ferdousi; Tahniyah  Haq; MA  Hasanat

doi:10.15605/jafes.038.02.09

Authors

Kishore Kumar shil Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Tahmina Ferdousi Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh https://orcid.org/0000-0003-0189-5232
Tahniyah Haq Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh https://orcid.org/0000-0002-0863-0619
MA Hasanat Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

DOI:

https://doi.org/10.15605/jafes.038.02.09

Keywords:

Sex Reversal Syndrome, 46XX with SRY positive, Genetic analysis

Abstract

We report a case of an SRY-positive 46,XX Indian male who presented with small testis and phallus, poor beard and mustache development and gynecomastia at the age of 24 years. He was biochemically found to have hypergonadotropic hypogonadism. He had 46,XX karyotype and Quantitative Fluorescence-PCR (QF-PCR) identified the SRY gene on the X chromosome. SRY-positive 46 XX male SRS cases usually present as phenotypically male since birth but develop features of hypogonadism, poor testicular development, and infertility after puberty. Infertility, hypogonadism, external genital development, and psychological distress are the major concerns during the management of the patients. Testosterone therapy for hypogonadism, artificial reproductive technologies for fertility, surgical repair of hypospadias/cryptorchidism/under-virilized genitalia and psychological and genetic counseling are helpful for proper management of the patients.

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Author Biographies

Kishore Kumar shil, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Resident, Department of Endocrinology

Tahmina Ferdousi, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Resident, Department of Endocrinology

Tahniyah Haq, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Assistant Professor, Department of Endocrinology

MA Hasanat, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Professor, Department of Endocrinology

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