Acute Adrenal Insufficiency as the Primary Manifestation of Extrapulmonary Tuberculosis: A Case Report

Authors

  • Herman Trianto Department of Internal Medicine, Faculty of Medicine Brawijaya University – dr. Saiful Anwar General Hospital
  • Nurria Betty Endocrinology, Metabolic Disease and Diabetes Division, Internal Medicine Department Brawijaya University - Saiful Anwar General Hospital Malang
  • Laksmi Sasiarini Endocrinology, Metabolic Disease and Diabetes Division, Internal Medicine Department Brawijaya University - Saiful Anwar General Hospital Malang
  • Rulli Rosandi Endocrinology, Metabolic Disease and Diabetes Division, Internal Medicine Department Brawijaya University - Saiful Anwar General Hospital Malang
  • Putu Arsana Endocrinology, Metabolic Disease and Diabetes Division, Internal Medicine Department Brawijaya University - Saiful Anwar General Hospital Malang
  • Djoko Soeatmadji Endocrinology, Metabolic Disease and Diabetes Division, Internal Medicine Department Brawijaya University - Saiful Anwar General Hospital Malang
  • Achmad Rudijanto Endocrinology, Metabolic Disease and Diabetes Division, Internal Medicine Department Brawijaya University - Saiful Anwar General Hospital Malang

Keywords:

Addison’s disease, acute adrenal insufficiency, serum cortisol, urinary symptoms, tuberculosis

Abstract

>Acute adrenal insufficiency (AI) is a life-threatening condition. While Addison’s disease (AD) is rare, in developing countries, tuberculosis (TB) still remains as the primary cause in 7 to 20% of cases. Urinary TB is also the third most common form of extrapulmonary disease. We report a case of 37-year-old male who presented with weakness, anorexia, weight loss, dysuria, flank pain and low grade fever. Examination revealed hypotension, hyperpigmentation, hyponatremia, hypoglycemia and low serum cortisol. He was diagnosed to have adrenal crisis due to Addison’s disease and extrapulmonary TB manifesting as urinary tract infection (UTI). He was treated with corticosteroids and anti-TB medications. Urologic reconstructive surgery was subsequently planned.

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Author Biography

Herman Trianto, Department of Internal Medicine, Faculty of Medicine Brawijaya University – dr. Saiful Anwar General Hospital

Supervisor, Consultant of Endocrinology and Metabolic Disease Division

References

Addison T. On the constitutional and local effects of disease of the supra-renal capsules. Medical History. 1969;13(2):195-202. http://dx.doi.org/10.1017/S0025727300014290.

Patnaik MM, Deshpande AK. Diagnosis –Addison’s disease secondary to tuberculosis of the adrenal glands. Clin Med Res. 2008; 6(1):29. http://dx.doi.org/10.3121/cmr.2007.754a.

Brooke AM, Monson JP. Addison’s disease. Medicine. 2009;37(8):416-9. http://dx.doi.org/10.1016/j.mpmed.2009.05.006.

Guttman PH. Addison’s disease: A statistical analysis of 566 cases and study of the pathology. Arch Path. 1930;10:742-85.

Kinjo T, Higuchi D, Oshiro Y, Nakamatsu Y, Fujita K, Nakamoto K, et al. Addison’s disease due to tuberculosis that required differentiation from SIADH. J Infect Chemother. 2009;15(4):239-42. http://dx.doi.org/10.1007/s10156-009-0690-Z.

Lam KY, Lo CY. A critical examination of adrenal tuberculosis and a 28-year autopsy. Clin Endocrinol (Oxf). 2001;54(5):633-9. http://10.1046/j.1365-2265.2001.01266.x.

Ma ES, Yang ZG, Li Y, Guo YK, Deng YP, Zhang XC. Tuberculous Addison’s disease: Morphological and quantitative evaluation with multidetector-row CT. Eur J Radiol. 2007;62(3):352-8. http://dx.doi.org/10.1016/j.ejrad.2006.12.012.

Yokoyama T, Toda R, Kimura Y, Mikagi M, Aizawa H. Addison’s disease induced by miliary tuberculosis and the administration of rifampicin. Inter Med. 2009;48(15):1297-300. http://doi.org/10.2169/internalmedicine.48.1974.

Zhang XC, Yang ZG, Li Y, Min PQ, Guo YK, Deng YP, et al. Addison’s disease due to adrenal tuberculosis: MRI features. Abdom Imaging. 2008;33(6):689-94. http://doi.org/10.1007/s00261-007-9352-8.

Nomura K, Demura H, Saruta T. Addison’s disease in Japan: Characteristics and changes revealed in a nationwide survey. Intern Med. 1994;33(10):602-6. http://doi.org/10.2169/internalmedicine.33.602.

Bhatia E, Jain SK, Gupta RK, Pandey R. Tuberculous Addison’s disease: Lack of normalization of adrenocortical function after anti-tuberculous chemotherapy. Clin Endocrinol (Oxf). 1998;48(3):355-9. http://doi.org/10.1046/j.1365-2265.1998.00409.x.

Guo YK, Yang ZG, Li Y, Ma ES, Deng YP, Min PQ, et al. Addison’s disease due to adrenal tuberculosis: Contrast-enhanced features and clinical duration correlation. Eur J Radiol. 2007;62(1):126-31. http://dx.doi.org/10.1016/j.ejrad.2006.11.025.

Rowińska-Zakrzewska E, Szopiński J, Remiszewski P, Szymański D, Miller P, Pawlicka L, et al. Tuberculosis in the autopsy material: Analysis of 1500 autopsies performed between 1972 and 1991 in the Institute of Tuberculosis and Chest Diseases, Warsaw, Poland. Tuber Lung Dis. 1995;76(4):349-54. http://dx.doi.org/10.1016/S0962-8479(05)80035-8.

Soule S. Addison’s disease in Africa- A teaching hospital experience. Clin Endocrinol (Oxf). 1999;50(1):115-20. http://dx.doi.org/10.1046/j.1365-2265.1999.00625.x.

Jacobi J, Schnellhardt S, Kulschewski A, Amann KU, Kuefner MA, Eckardt KU, et al. An unusual case of hyponatraemia. Nephrol Dial Transplant. 2010;25(3):998-1001. http://dx.doi.org/10.1093/ndt/gfp698.

Dorin RI, Qualls CR, Crapo LM. Diagnosis of adrenal insufficiency. Ann Intern Med. 2003; 139(3):194-204. http://dx.doi.org/10.7326/0003-4819-139-3-200308050-00017.

Upadhyay J, Sudhindra P, Abraham G, Trivedi N. Tuberculosis of the adrenal gland: A case report and review of the literature of infections of the adrenal glands. Int J Endocrinol. 2014;2014:876037. http://dx.doi.org/10.1155/2014/876037.

Wise GJ, Marella VK. Genitourinary manifestations of tuberculosis. Urol Clin North Am. 2003;30(1):111-21. PMID: 12580563.

Kelestimur F. Recovery of adrenocortical function following treatment of tuberculous Addison’s disease. Postgrad Med J. 1993;69(816):832-4. http://dx.doi.org/10.1136/pgmj.69.816.832.

Visweswaran RK, Bhat S. Tuberculosis of the urinary tract. In: Comprehensive Clinical Nephrology. J Floege, RJ Johnson, J Feehally, eds. 4th ed. St. Louis: Elsevier Saunders, 2010.

Dąbrowska A, Tarach J, Prystupa A, Kurowska M. Addison’s disease due to tuberculosis of the adrenal glands. Journal of Pre-Clin Clin Res. 2012;6(2):88-92.

Bancos I, Hahner S, Tomlinson J, Arlt W. Diagnosis and management of adrenal insufficiency. Lancet Diabetes Endocrinol. 2015;3(3):216-26. http://dx.doi.org/10.1016/S2213-8587(14)70142-1.

Published

2016-05-26

How to Cite

Trianto, H., Betty, N., Sasiarini, L., Rosandi, R., Arsana, P., Soeatmadji, D., & Rudijanto, A. (2016). Acute Adrenal Insufficiency as the Primary Manifestation of Extrapulmonary Tuberculosis: A Case Report. Journal of the ASEAN Federation of Endocrine Societies, 31(1), 59. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/256

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Section

Case Reports

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