Fructosamine and HbA1c: A Correlational Study in a Southeast Asian Population

Kurumbian Chandran; See Muah Lee; Liang Shen; Eng Loon Tng

doi:10.15605/jafes.039.01.14

Authors

Kurumbian Chandran Ng Teng Fong General Hospital https://orcid.org/0000-0002-9321-7705
See Muah Lee Ng Teng Fong Hospital https://orcid.org/0009-0000-6268-9200
Liang Shen University of Singapore https://orcid.org/0000-0001-7976-668X
Eng Loon Tng Raffles Hospital

DOI:

https://doi.org/10.15605/jafes.039.01.14

Keywords:

Nil

Abstract

Objectives. Fructosamine correlates well with glycated haemoglobin (HbA1c) in Caucasians. This study investigates this correlation and whether fructosamine can reliably estimate glycated haemoglobin in Southeast Asians.

Methodology. We recruited 193 participants based on 4 HbA1c bands (<6.0%; 6.0 – 7.9%; 8.0– 9.9%; ≥10%) from a secondary hospital in Singapore between August 2017 and December 2021. Blood samples for fructosamine, glycated haemoglobin, albumin, haemoglobin, thyroid stimulating hormone and creatinine were drawn in a single setting for all participants. Scatter plot was used to explore correlation between fructosamine and glycated haemoglobin. Strength of linear correlation was reported using Pearson’s correlation coefficient. Simple linear regression was used to examine the relationship between fructosamine and glycated haemoglobin.

Results. We performed simple linear regression to study the relationship between fructosamine and HbA1c in the research participants (R²= 0.756, p<0.01). Further analysis with natural logarithmic transformation of fructosamine demonstrated a stronger correlation between HbA1c and fructosamine (R²= 0.792, p<0.01).

Conclusions. Fructosamine is reliably correlated with HbA1c for the monitoring of glycaemic control in Southeast Asians.

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Author Biographies

Kurumbian Chandran, Ng Teng Fong General Hospital

National University Health System, Department of Medicine, Ng Teng Fong Hospital, Singapore

See Muah Lee, Ng Teng Fong Hospital

National University Health System, Department of Medicine, Ng Teng Fong Hospital, Singapore

Liang Shen, University of Singapore

Yong Loo Lin School of Medicine, University of Singapore

Eng Loon Tng, Raffles Hospital

Raffles Medical, Raffles Hospital, Singapore

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