CHROMOGRANIN-POSITIVE ALDOSTERONE-PRODUCING ADRENOCORTICAL CARCINOMA WITH CORTISOL CO-SECRETION

A CASE REPORT

Authors

  • Megan Margrethe Balina

Keywords:

adrenocortical carcinoma, aldosterone, cortisol, ACC, chromogranin-positive

Abstract

CASE
A 45-year-old Filipino female consulted due to persistent bilateral lower-extremity weakness associated with poorly-controlled hypertension on triple anti-hypertensive medications, recurrent spontaneous hypokalemia, elevated plasma aldosterone concentration (PAC), suppressed plasma renin activity (PRA), elevated PAC/PRA ratio at 318.29 ng/dL per ng/mL/hour, and a nonsuppressed 8 am serum cortisol at 11.6 ug/dL after 1 mg overnight dexamethasone suppression test. A computed tomography scan of the abdomen (adrenal protocol) showed a heterogeneously enhancing right adrenal mass measuring 6.2 x 6.5 x 9.5 cm (previously 4.6 x 5.3 x 6.3 cm), exhibiting intralesional vascularity and areas of necrosis, with mass effect to the liver, right kidney, and inferior vena cava. She underwent an open right adrenalectomy with the removal of a 9.5 x 6.8 x 5.0 cm encapsulated mass. The histopathology report revealed a low-grade adrenocortical carcinoma.

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Author Biography

Megan Margrethe Balina

University of Santo Tomas Hospital, Manila, Philippines

References

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Published

2023-11-09

How to Cite

Balina, M. M. (2023). CHROMOGRANIN-POSITIVE ALDOSTERONE-PRODUCING ADRENOCORTICAL CARCINOMA WITH CORTISOL CO-SECRETION: A CASE REPORT. Journal of the ASEAN Federation of Endocrine Societies, 38(S3), 38. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/3265

Issue

Vol. 38 No. S3 (2023): AFES Book of Abstracts (Supplement)

Section

Poster Presentation | Adrenal

License

Copyright (c) 2023 Megan Margrethe Balina

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