THE PREVALENCE OF VITAMIN D DEFICIENCY IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE AND T2DM

Authors

  • Nur Aini Eddy Warman
  • Fatimah Zaherah Mohamed Shah
  • Mohd Hazriq Awang
  • Nur Aisyah Zainordin
  • Aimi Fadilah Mohamad
  • Rohana Abdul Ghani

Keywords:

vitamin D deficiency, type 2 diabetes mellitus, nonalcoholic fatty liver disease, insulin, ultrasound

Abstract

INTRODUCTION
Vitamin D has been shown to have anti-inflammatory effects and its deficiency is associated with increased risk of type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD). Vitamin D deficiency is prevalent in patients with T2DM and NAFLD.

METHODOLOGY
This study aimed to determine the prevalence of vitamin D deficiency in patients with both T2DM and NAFLD. We conducted a cross-sectional study in adult patients with T2DM, and they were divided into 2 groups: patients with T2DM and NAFLD (n = 86) and patients with T2DM without NAFLD (n=24). The definition of NAFLD was based on the presence of liver steatosis via ultrasound abdomen. Serum total 25-hydroxy-D3 (vitamin D) level was analysed using electrochemiluminescence immunoassay and defined as deficient if the level was <50 nmol/L. The sample size calculated was 47 patients per group.

RESULTS
The prevalence of vitamin deficiency in the overall population was 48.2% (53/110). There was a numerically higher prevalence of vitamin D deficiency in patients with T2DM and NAFLD compared to those without NAFLD (52.3% (45/86) vs 33.3% (8/24), p=0.1). The mean serum vitamin D levels of patients with T2DM and NAFLD were statistically lower than those without NAFLD (51.53 ± 19.68 vs 60.61 ± 20.25; p <0.05). These differences were seen despite no significant difference in age, diabetes duration, insulin dose, BMI, weight circumference, HbA1c, LDL-c, HDL-c, triglycerides, and interleukin-6 levels between the NAFLD and no NAFLD group.

CONCLUSION
This study demonstrated a high prevalence of vitamin D deficiency in patients with T2DM and NAFLD. Patients with T2DM and NAFLD have lower vitamin D level as compared to those with T2DM alone.

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Author Biographies

Nur Aini Eddy Warman

Medical Faculty Universiti Teknologi MARA (UiTM), Selangor, Malaysia

Fatimah Zaherah Mohamed Shah

Medical Faculty Universiti Teknologi MARA (UiTM), Selangor, Malaysia

Mohd Hazriq Awang

Medical Faculty Universiti Teknologi MARA (UiTM), Selangor, Malaysia

Nur Aisyah Zainordin

Medical Faculty Universiti Teknologi MARA (UiTM), Selangor, Malaysia

Aimi Fadilah Mohamad

Medical Faculty Universiti Teknologi MARA (UiTM), Selangor, Malaysia

Rohana Abdul Ghani

Medical Faculty Universiti Teknologi MARA (UiTM), Selangor, Malaysia

References

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Published

2023-11-09

How to Cite

Warman, N. A. E., Shah, . F. Z. M. ., Awang, M. H., Zainordin, N. A., Mohamad, A. F. ., & Ghani, R. A. (2023). THE PREVALENCE OF VITAMIN D DEFICIENCY IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE AND T2DM. Journal of the ASEAN Federation of Endocrine Societies, 38(S3), 48. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/3309

Issue

Section

Poster Presentation | Bone and Calcium

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