ANTHROPOMETRIC, BIOCHEMICAL AND IMAGING CHARACTERISTICS OF FEMALES WITH DIABETES AND FAMILIAL PARTIAL LIPODYSTROPHY

Authors

  • Wann Jia Loh
  • Joan Khoo
  • Yaligar Jadegoud
  • Suresh Anand Sadananthan
  • Amanda Hooper
  • Yeshe Kway
  • Sambasivam Sendhil Velan
  • Su Chi Lim
  • Melvin Khee Shing Leow

Keywords:

lipodystrophy, severe insulin resistance, MRI, diabetes, obesity

Abstract

INTRODUCTION
Familial partial lipodystrophy (FPL) is an under recognized condition characterized by an increased genetic predisposition to abnormalities in white adipose tissue function, quantity, and distribution, leading to youngonset metabolic syndrome including type 2 diabetes mellitus (T2DM). However, in clinical practice, there are no clear criteria to diagnose FPL. This pilot study aimed to determine clinical markers using skinfold measurements, DXA, and MRI scans to identify individuals with FPL and to characterize their adipose tissue distribution and fat phenotypes.

METHODOLOGY
In 8 females with FPL and 4 BMI-matched female controls, skinfold measurements, HOMA-IR, whole genome sequencing, and DXA were performed. MRI was used to measure abdominal subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and femoral and calf SAT and muscle volumes.

RESULTS
Both groups’ median BMI were 32-33 kg/m2. All eight patients in the FPL group had T2DM with median disease onset at age 31 years. FPL, when compared to controls, had higher levels of HOMA-IR (p = 0.028), reduced thigh skinfold thickness (20.4 mm vs 51.4 mm, p = 0.008) with a correspondingly increased subscapular-to-thigh skinfold ratio (p = 0.004), and iliac-to-thigh skinfold ratio (p = 0.004). The FPL group had a reduced leg fat percentage (34.6 vs 48.1, p = 0.004) with an increased ratio of trunk-to-legs fat percentage (1.36 vs 0.98, p = 0.004), and android to gynoid ratio (1.21 vs 0.98, p = 0.008). The FPL group had decreased SAT volume in the femoral and calf.

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Author Biographies

Wann Jia Loh

Changi General Hospital, Singapore

Joan Khoo

Changi General Hospital, Singapore

Yaligar Jadegoud

Singapore Institute for Clinical Sciences, Agency for Science Technology, Singapore

Suresh Anand Sadananthan

Singapore Institute for Clinical Sciences, Agency for Science Technology, Singapore

Amanda Hooper

Pathwest and Fiona Stanley Hospital Network, Australia

Yeshe Kway

Singapore Institute for Clinical Sciences, Agency for Science Technology, Singapore

Sambasivam Sendhil Velan

Singapore Institute for Clinical Sciences, Agency for Science Technology, Singapore

Su Chi Lim

Diabetes Centre, Admiralty Medical Centre, Singapore, Singapore

Melvin Khee Shing Leow

Tan Tock Seng Hospital, Singapore

References

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Published

2023-11-09

How to Cite

Loh, W. J., Khoo, J., Jadegoud, Y. ., Sadananthan, . S. A. ., Hooper, A., Kway, Y. ., … Leow, M. K. S. (2023). ANTHROPOMETRIC, BIOCHEMICAL AND IMAGING CHARACTERISTICS OF FEMALES WITH DIABETES AND FAMILIAL PARTIAL LIPODYSTROPHY. Journal of the ASEAN Federation of Endocrine Societies, 38(S3), 51. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/3321

Issue

Section

Poster Presentation | Diabetes