A RARE CASE OF MICROPROLACTINOMA AND GRANULOMATOUS MASTITIS

Authors

  • Kai Xuan Teh
  • Hwee Ching Tee
  • Jin Hui Ho
  • Joon Hi Tham
  • Ann Feng Pan

Keywords:

MICROPROLACTINOMA, GRANULOMATOUS MASTITIS, IGM

Abstract

INTRODUCTION/BACKGROUND
Idiopathic granulomatous mastitis (IGM) is a benign and rare chronic inflammatory disease of the breast. However, its clinical presentation can mimic a breast malignancy or abscess. The aetiology is often unknown but several predisposing factors were identified, including patients with autoimmune disorders, hyperprolactinemia secondary to pregnancy, lactation, dopamine antagonist usage or pituitary adenoma.

CASE
We report a rare case of IGM in a patient with hyperprolactinemia secondary to microprolactinoma. A 45-year-old, para 2, premenopausal female presented to a surgical clinic with a 2 year history of intermittent bilateral galactorrhoea and right breast swelling with pus discharge. There was no menstrual irregularity. Ultrasound of the right breast demonstrated multiloculated hypoechoic collections with internal echogenicities. She was treated with antibiotics; however, there was no clinicalimprovement, and she underwent biopsy of the lesion
which revealed chronic granulomatous inflammation, confirming the diagnosis of IGM. She was also found to have hyperprolactinemia at 125.9 ng/ml secondary to a microprolactinoma and was started on cabergoline. Two weeks post treatment, the prolactin level normalized with resolution of galactorrhoea.

CONCLUSION
Hyperprolactinemia is one of the predisposing factors for the development of IGM by increasing inflammation of the breast tissue. When evaluating for IGM, serum prolactin should always be measured to exclude elevated prolactin levels. The cause of hyperprolactinemia should be further investigated and addressed, and treatment with dopamine receptor agonist could reduce recurrence of IGM. 

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Author Biographies

Kai Xuan Teh

Endocrinology Unit, Department of Internal Medicine, Hospital Queen Elizabeth II, Kota Kinabalu, Sabah, Malaysia

Hwee Ching Tee

Endocrinology Unit, Department of Internal Medicine, Hospital Queen Elizabeth II, Kota Kinabalu, Sabah, Malaysia

Jin Hui Ho

Endocrinology Unit, Department of Internal Medicine, Hospital Queen Elizabeth II, Kota Kinabalu, Sabah, Malaysia

Joon Hi Tham

Department of Pathology, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia

Ann Feng Pan

Department of Pathology, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia

References

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Published

2023-07-06

How to Cite

Teh, K. X., Tee, H. C., Ho, J. H., Tham, J. H., & Pan, A. F. (2023). A RARE CASE OF MICROPROLACTINOMA AND GRANULOMATOUS MASTITIS. Journal of the ASEAN Federation of Endocrine Societies, 38(S2), 48–49. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/3815