Conversion of Primary Hypothyroidism to Hyperthyroidism: A Case Report

Keywords: hypothyroidism, Graves’ disease, antithyroid drugs, Carbimazole, agranulocytosis


A 51-year-old male developed Graves’ thyrotoxicosis following long-standing treatment for hypothyroidism. After a short period of treatment with Carbimazole, he developed agranulocytosis and he required total thyroidectomy. In this relevant case report, we review several pathogenetic mechanisms that explain the transformation of auto-immune hypothyroidism into Graves’ disease and the possible approaches to the management of agranulocytosis secondary to antithyroid medications.

Further studies are required to determine the best way to manage severe thyrotoxicosis when agranulocytosis develops due to antithyroid medications.



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Author Biographies

Liam Clifford, Wyong Hospital, New South Sales
Resident Medical officer
Ammar Wakil, Wyong Hospital, New South Wales
Department of Endocrinology


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How to Cite
Clifford, L., & Wakil, A. (2018). Conversion of Primary Hypothyroidism to Hyperthyroidism: A Case Report. Journal of the ASEAN Federation of Endocrine Societies, 33(2), 190. Retrieved from
Case Reports