Reninoma

A Rare Cause of Surgically Curable Hypertension and Secondary Hyperaldosteronism

Authors

  • Gaayathri Krishnan Hospital Queen Elizabeth, Kota, Kinabalu, Sabah, Malaysia https://orcid.org/0000-0002-8514-7604
  • Lim Jing Li Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia
  • Tee Hwee Ching Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia
  • Serena Khoo Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia https://orcid.org/0000-0001-7918-0929

DOI:

https://doi.org/10.15605/jafes.040.02.20

Keywords:

reninoma, renin, hypertension

Abstract

Reninoma is a rare cause of renin-induced hypertension commonly seen in young adults and adolescents. Here, we describe a case of reninoma presenting with hypertension in the young. Further investigation revealed elevated renin and aldosterone levels. Computed tomography of the kidneys showed a right-sided renal mass. A diagnosis of reninoma was made, and the patient underwent nephron-sparing surgery, which rendered her normotensive post-operatively.

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Author Biographies

Gaayathri Krishnan, Hospital Queen Elizabeth, Kota, Kinabalu, Sabah, Malaysia

Endocrinology Unit, Hospital Queen Elizabeth, Kota, Kinabalu, Sabah, Malaysia

Lim Jing Li, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia

Medical Officer, Endocrinology Unit, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia

Tee Hwee Ching, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia

Endocrinology Unit, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia

Serena Khoo, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia

Endocrinology Unit, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia

References

1. Wang B, Ding L, Xu S, et al. A case of atypical reninoma with mild hypertension and normal plasma renin activity but elevated plasma renin concentration. BMC Endocr Disord. 2022;22(1):71. https://pubmed.ncbi.nlm.nih.gov/35303838 https://pmc.ncbi.nlm.nih.gov/articles/PMC8932068 https://doi.org/10.1186/s12902-022-00977-w

2. Wong L, Hsu TH, Perlroth MG, Hofmann LV, Haynes CM, Katznelson L. Reninoma: Case report and literature review. J Hypertens. 2008;26(2):368-73. https://pubmed.ncbi.nlm.nih.gov/18192852 https://doi.org/10.1097/HJH.0b013e3282f283f3

3. Shera AH, Baba AA, Bakshi IH, Lone IA. Recurrent malignant juxtaglomerular cell tumor: A rare cause of malignant hypertension in a child. J Indian Assoc Pediatr Surg. 2011;16(4):152-4. https://pubmed.ncbi.nlm.nih.gov/22121315 https://pmc.ncbi.nlm.nih.gov/articles/PMC3221159 https://doi.org/10.4103/0971-9261.86876

4. Diker-Cohen T, Abraham SB, Rauschecker M, et al. Reninoma presenting in pregnancy. J Clin Endocrinol Metab. 2014;99(8):2625-6. https://pubmed.ncbi.nlm.nih.gov/24848711 https://pmc.ncbi.nlm.nih.gov/articles/PMC4121021 https://doi.org/10.1210/jc.2014-1730

5. Bealer SL. Systemic angiotensin II alters intrinsic heart rate through central mechanisms. Brain Res Bull. 2002;58(1):61-5. https://pubmed.ncbi.nlm.nih.gov/12121814 https://doi.org/10.1016/s0361-9230(02)00756-6

6. Rosei CA, Giacomelli L, Salvetti M, et al. Advantages of renin inhibition in a patient with reninoma. Int J Cardiol. 2015;187:240-2. https://pubmed.ncbi.nlm.nih.gov/25838223 https://doi.org/10.1016/j.ijcard.2015.03.280

7. Liu K, Wang B, Ma X, et al. Minimally invasive surgery-based multidisciplinary clinical management of reninoma: A single-center study. Med Sci Monit. 2019;25:1600-10. https://pubmed.ncbi.nlm.nih.gov/30822300 https://pmc.ncbi.nlm.nih.gov/articles/PMC6407327 https://doi.org/10.12659/MSM.913826

8. Wolley M, Gordon RD, Stowasser M. Reninoma: The importance of renal vein renin ratios for lateralisation and diagnosis. Am J Nephrol. 2014;39(1):16-9. https://pubmed.ncbi.nlm.nih.gov/24401674 https://doi.org/10.1159/000357410

9. Vidal-Petiot E, Bens M, Choudat L, et al. A case report of reninoma: Radiological and pathological features of the tumour and characterization of tumour-derived juxtaglomerular cells in culture. J Hypertens. 2015;33(8):1709-15. https://pubmed.ncbi.nlm.nih.gov/26132761 https://doi.org/10.1097/HJH.0000000000000592.

10. Zhang R, Xu M, Xie XY. The role of real-time contrast-enhanced ultrasound in guiding radiofrequency ablation of reninoma: Case report and literature review. Front Oncol. 2021;11:585257. https://pubmed.ncbi.nlm.nih.gov/33686368 https://pmc.ncbi.nlm.nih.gov/articles/PMC7935754 https://doi.org/10.3389/fonc.2021.585257

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Published

2025-11-07

How to Cite

Krishnan, G., Li, L. J., Ching, T. H., & Khoo, S. (2025). Reninoma: A Rare Cause of Surgically Curable Hypertension and Secondary Hyperaldosteronism. Journal of the ASEAN Federation of Endocrine Societies, 40(2), 165–168. https://doi.org/10.15605/jafes.040.02.20

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Section

Case Reports