Who were those MEN hiding behind the Ulcers?

A Case Report

Keywords: MEN1, gastrinoma, octreotide LAR, meningioma

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disease caused by a mutation in the
MEN1 gene. We present a 65-year-old man with MEN1 who has primary hyperparathyroidism, microprolactinoma, meningioma and gastrinoma. He had undergone parathyroidectomy followed by tumour excision of meningioma. The duodenal gastrinoma lesion was inoperable as it was close to the superior mesenteric artery with high surgery risk. Medical therapy with octreotide LAR had been initiated and showed good biochemical response as well as disease progression control. Chemoembolization was proposed if the duodenum lesion reduces in size on maintenance treatment with octreotide LAR. This case highlights the challenges in managing this rare condition and octreotide LAR has shown to be effective in controlling the disease progression in MEN1 with inoperable gastrinoma.

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Author Biographies

Shazatul Reza Binti Mohd Redzuan, Hospital Tengku Ampuan Rahimah

Endocrine Unit, Endocrine Unit, Medical Department,

Yong Sy Liang, Hospital Tengku Ampuan Rahimah

Endocrine Unit, Medical Department

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Published
2020-10-30
How to Cite
Redzuan, S. R. B. M., & Liang, Y. S. (2020). Who were those MEN hiding behind the Ulcers? A Case Report. Journal of the ASEAN Federation of Endocrine Societies, 35(2). Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/797
Section
Case Reports