Dermopathy, Acropachy and Orbitopathy in Graves’ Disease


  • James Young Section of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, St. Luke’s Medical Center, Quezon City, Philippines
  • Michael Villa Section of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, St. Luke’s Medical Center, Quezon City, Philippines


dermopathy, acropachy, orbitopathy, Graves’ Disease


A 56-year-old Filipino male presented with bilateral lower limb swelling. The patient was a known smoker with a one-year history of Graves’ disease. He was initially treated with methimazole for control of thyrotoxicosis. Five months prior to consultation, he was given oral radioactive iodine (Iodine-131) for the definitive treatment of his thyroid disease.


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Bartalena L, Tanda ML. Clinical practice. Graves’ opthalmopathy. N Engl J Med. 2009;360(10):994-1001. PMID: 19264688.

Marino M, Chiovato L, Pinchera A. Graves’ Disease. In: Jameson JL, De Groot LJ, eds. Endocrinology Adult and Pediatric. 6th Edition. Philadelphia: Saunders; 2010:1527-71.

Davies TF, Larsen PR. Thyrotoxicosis. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th Edition. Philadelphia: Saunders; 2008:333-75.

Fatourechi V, Pajouhi M, Fransway AF. Dermopathy of Graves’ disease (pretibial myxedema): Review of 150 cases. Medicine (Baltimore). 1994;73(1):1-7. PMID: 8309359.

Tiu SC, Choi CH. Elephantiasic thyroid dermopathy. Hong Kong Med J. 2006;12(2):159-60. PMID: 16603786.

Fatourechi V, Ahmed DD, Schwartz KM. Thyroid acropachy: Report of 40 patients treated at a single institution in a 26-year period. J Clin Endocrinol Metab. 2002;87:5435-41. PMID: 12466333.

Anderson CK, Miller OF 3rd. Triad of exophthalmos, pretibial myxedema and acropachy in a patient with Graves’ disease. J Am Acad Dermatol 2003;48(6):970-2. PMID: 12789197.

Bartalena L, Baldeschi L, Dickinson A, Eckstein A, Kendall-Taylor P, Marcocci C, et al. Consensus statement of the European Group on Graves’ orbitopathy (EUGOGO) on management of GO. Eur J Endocrinol. 2008;158(3):273–85. PMID: 18299459.

Dickinson J, Perros P. Thyroid-associated orbitopathy: Who and how to treat. Endocrinol Metab Clin North Am. 2009;38(2):373–88. PMID: 19328417.

Antonelli A, Saracino A, Agostini S, Alberti B, Melosi A, Gambuzza C, et al. Results of high-dose intravenous immunoglobulin treatment of patients with pretibial myxedema and Basedow’s disease: Preliminary findings. Clin Ter. 1992;141(9 Pt 2):63-8. PMID: 1281765.



How to Cite

Young, J., & Villa, M. (2014). Dermopathy, Acropachy and Orbitopathy in Graves’ Disease. Journal of the ASEAN Federation of Endocrine Societies, 26(1), 71. Retrieved from



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