A Rare Case of Bilateral Non-Hodgkin’s Lymphoma of the Adrenal Gland

Main Article Content

Maria Patricia Puno
Sheila Cagadas
Michael Villa


Bilateral Adrenal Lymphoma is a rare disease which, when it is discovered, may be associated with adrenal insufficiency. We report a case of an 81-year-old female, with no known co-morbidities, presenting with anorexia and flank pain. Initial CT imaging revealed bilateral adrenal masses measuring 6.4 x 7.4 cm on the right and 5.9 x 5.8 cm on the left with subsequent scans showing the masses to be rapidly enlarging.  Aspiration biopsy revealed Non-Hodgkin’s Lymphoma, diffuse large B cell type.  She underwent chemotherapy with almost complete resolution of the adrenal tumors.


Download data is not yet available.

Article Details

How to Cite
Patricia Puno, M., Cagadas, S., & Villa, M. (2014). A Rare Case of Bilateral Non-Hodgkin’s Lymphoma of the Adrenal Gland. Journal of the ASEAN Federation of Endocrine Societies, 27(2), 221. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/42
Case Reports


Yap, M and Tiangco, B. Clinicopathologic profile of Filipino patients with malignant lymphomas. Phil J Internal Medicine. Nov – Dec 2004: 42: 289-296.

Ozimek, Alexandra, et al. Bilateral Primary Adrenal Non-Hodgkin's Lymphoma and Primary Adrenocortical Carcinoma – Review of the literature preoperative differentiation of adrenal tumors. Endocrine Journal 2008; 55 (4), 625-638.

Aziz, SA et al. Primary Adrenal Lymphoma: Differential involvement with varying adrenal function. Indian Journal of Endocrinology and Metabolism. 2011; 15 (3).

Ozimek, A et al. Bilateral Primary Adrenal Non-Hodgkin's Lymphoma – A case report and review of the literature. Eur J Med Res 2008; 13: 221-228.

Kim et al, A case of Primary Adrenal Diffuse Large B-cell Lymphoma achieving complete remission with Rituximab-CHOP Chemotherapy. J Korean Med Sci 2009; 24: 525-8.

Horiguchi, K et al. Primary Bilateral Adrenal Diffuse Large B-cell Lymphoma demonstrating adrenal failure. Inter Med. 2010: 49; 2241-2246.

Young, W. The incidentally discovered adrenal mass. N Engl J Med. 2007; 356:601-10.

Dobrinja, C et al. Primary Bilateral Adrenal Non-Hodgkin’s Burkitt-Like Lymphoma: A rare cause of primary adrenal insufficiency. Case report and literature review. Tumori. 2007; 93(6): 625-30.

Nieman, L. Approach to the patient with an adrenal incidentaloma. J Clin Endocrinol Metab. 2010: 95; 4106–4113.

Welch TJ, et al. Percutaneous adrenal biopsy: Review of a 10-year experience. Radiology. 1994; 193:341-4.

Terzolo, M et al. AME Position Statement on adrenal incidentaloma. European Journal of Endocrinology. 2011: 164; 851–870.

Reddy, S et al. Origin of primary adrenal lymphoma and predisposing factors for primary adrenal insufficiency in primary adrenal lymphoma. Indian J Endocrinol Metab. 2011 Oct-Dec; 15(4) 350-351.

Ellis, RD and Read, D. Bilateral adrenal non-Hodgkin’s lymphoma with adrenal insufficiency. Postgrad Med J. 2000; 76:508–509.

Kumar, R et al. FDG-PET imaging in Primary Bilateral Adrenal Lymphoma: A case report and review of literature. Clinical Nuclear Medicine 2005; 30: 222-230.

Grigg, A and Connors, J. Primary Adrenal Lymphoma. Clin Lymphoma 2003; 4: 154-160.

Kim, Y et al. Prognostic factors in primary diffuse large B-cell lymphoma of adrenal gland treated with rituximab-CHOP chemotherapy from the Consortium for Improving Survival of Lymphoma (CISL). Journal of Hematology & Oncology 2012; 5 (49): 1-9.

Most read articles by the same author(s)