Review of Literature on Akkermansia muciniphila and its Possible Role in the Etiopathogenesis and Therapy of Type 2 Diabetes Mellitus

Made Indira Dianti Sanjiwani; I Putu Hendri Aryadi; I Made Siswadi Semadi

doi:10.15605/jafes.037.01.13

Authors

Made Indira Dianti Sanjiwani Udayana University, Denpasar, Bali, Indonesia https://orcid.org/0000-0001-7980-6696
I Putu Hendri Aryadi Udayana University, Bali, Indonesia https://orcid.org/0000-0003-4206-2245
I Made Siswadi Semadi Udayana University, Bali, Indonesia

DOI:

https://doi.org/10.15605/jafes.037.01.13

Keywords:

Akkermansia muciniphila, ER stress, gut microbiota, insulin resistance, probiotic, type 2 diabetes mellitus

Abstract

Akkermansia muciniphila is a promising gut microbiota for the treatment of type 2 diabetes mellitus (T2DM). A. muciniphila stimulates intestinal wall integrity, is an anti-inflammatory agent, and reduces endoplasmic reticulum stress, lipogenesis and gluconeogenesis. These properties make A. muciniphila a potential treatment option for T2DM by reducing insulin resistance and increasing insulin sensitivity and glucose tolerance in different tissues. This article explores the possible role of A. muciniphila in T2DM management, along with the various methods known to modulate A. muciniphila.

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Author Biographies

Made Indira Dianti Sanjiwani, Udayana University, Denpasar, Bali, Indonesia

Faculty of Medicine

I Putu Hendri Aryadi, Udayana University, Bali, Indonesia

Faculty of Medicine

I Made Siswadi Semadi, Udayana University, Bali, Indonesia

Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine

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