Review of Literature on Akkermansia muciniphila and its Possible Role in the Etiopathogenesis and Therapy of Type 2 Diabetes Mellitus

Main Article Content

Made Indira Dianti Sanjiwani
https://orcid.org/0000-0001-7980-6696
I Putu Hendri Aryadi
https://orcid.org/0000-0003-4206-2245
I Made Siswadi Semadi

Abstract

Akkermansia muciniphila is a promising gut microbiota for the treatment of type 2 diabetes mellitus (T2DM). A. muciniphila stimulates intestinal wall integrity, is an anti-inflammatory agent, and reduces endoplasmic reticulum stress, lipogenesis and gluconeogenesis. These properties make A. muciniphila a  potential treatment option for T2DM by reducing insulin resistance and increasing insulin sensitivity and glucose tolerance in different tissues. This article explores the possible role of A. muciniphila in T2DM management, along with the various methods known to modulate A. muciniphila.

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How to Cite
Sanjiwani, M. I. D., Aryadi, I. P. H., & Semadi, I. M. S. (2022). Review of Literature on Akkermansia muciniphila and its Possible Role in the Etiopathogenesis and Therapy of Type 2 Diabetes Mellitus. Journal of the ASEAN Federation of Endocrine Societies, 37(1), 69–74. https://doi.org/10.15605/jafes.037.01.13
Section
*Review Articles
Author Biographies

Made Indira Dianti Sanjiwani, Udayana University, Denpasar, Bali, Indonesia

Faculty of Medicine

I Putu Hendri Aryadi, Udayana University, Bali, Indonesia

Faculty of Medicine

I Made Siswadi Semadi, Udayana University, Bali, Indonesia

Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine

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