Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, Indonesia
DOI:
https://doi.org/10.15605/jafes.039.02.15Keywords:
elderly, IGF-1, waist circumferenceAbstract
Background. Hyperinsulinemia due to insulin resistance is hypothesized to act as a promotor of cancer growth. In addition to the direct effects of hyperinsulinemia on cancer cells, the stimulation of tumor cell growth can also be indirectly mediated through growth factors and receptors such as insulin-like growth factor 1 (IGF-1). Increased cancer risk is also associated with increased adipose tissue, such as in abdominal obesity, due to the higher risk of insulin resistance and hyperinsulinemia. Waist circumference is a parameter that indicates an individual's level of adiposity. In addition, the risk of cancer also increases in the elderly as they age. This study aims to assess the correlation between waist circumference and IGF-1 levels in the elderly population in Bali, Indonesia.
Methodology. This study used a cross-sectional analytical design conducted in the Melinggih Village, Gianyar Regency. The study was conducted in September 2023. This study has been approved by the Research Ethics Commission number 2020/UN14.2.2.VII.14/LT/2023. The study population included elderly individuals residing in the Melinggih Village who were willing to participate. Data analysis encompassed descriptive analysis and the Spearman correlation test.
Result. A total of 88 subjects participated in the study, consisting of 57 females (64.8%) and 31 males (35.2%).
A statistically significant but weak correlation coexists between waist circumference and IGF-1 levels.
Conclusion. A weak but statistically significant positive correlation was found between waist circumference and IGF-1 levels in the elderly. However, because of the small sample size, another study with a bigger sample size with enough power to investigate this association needs to be done to validate the results of the current study.
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References
Fang H, Yao B, Yan Y, et al. Diabetes mellitus increases the risk of bladder cancer: an updated meta-analysis of observational studies. Diabetes Technol Ther. 2013;15(11):914-22. https://pubmed.ncbi.nlm.nih.gov/24180357 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817892 https://doi.org/10.1089/dia.2013.0131
Currie CJ, Poole CD, Gale EAM. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia. 2009;52(1):1766–77. https://pubmed.ncbi.nlm.nih.gov/19572116 https://doi.org/10.1007/s00125-009-1440-6
Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD, Evans JM. New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care. 2009;32(1):1620–5. https://pubmed.ncbi.nlm.nih.gov/19564453 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732153 https://doi.org/10.2337/dc08-2175
Torrisi R, Mezzetti M, Johansson H, Barreca A, Pigatto F, Robertson C, Decensi A. Time course of fenretinide-induced modulation of circulating insulin-like growth factor (IGF)-I, IGF-II and IGFBP-3 in a bladder cancer chemoprevention trial. Int J Cancer. 2000;87(1):601–5. https://pubmed.ncbi.nlm.nih.gov/10918204 https://doi.org/10.1002/1097-0215(20000815)87:4<601::aid-ijc22>3.0.co;2-w
Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009; 9(1):798–809. https://pubmed.ncbi.nlm.nih.gov/19851315 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856025 https://doi.org/10.1038/nrc2734
World Health Organization. Regional Office for the Western Pacific. The Asia-Pacific perspective: redefining obesity and its treatment. Sydney: Health Communications Australia; 2000. https://iris.who.int/bitstream/handle/10665/206936/0957708211_eng.pdf.
Accessed on May 18, 2024.
Idaiani S, Jovina TA., Mogsa DF., Pancaharjono W. Obesity and the risk of breast tumors in Indonesian women based on clinical breast examination. Thai J Pub Heath. 2020; 50(2): 161-75.
Wulandari GP, Kristina SA. Cancers attributable to obesity in Indonesia: a prevalence based study using disability adjusted life years. Glob J Health Sci. 2018; 10(8): 21-7. https://doi.org/10.5539/gjhs.v10n8p21
Solikhah S, Perwitasari D, Permatasari TAE, Safitri RA. Diet, obesity, and sedentary lifestyle as risk factor of breast cancer among women at Yogyakarta province in Indonesia. Open Access Maced J Med Sci. 2022;10(E):398–405. https://doi.org/10.3889/oamjms.2022.7228.
Garvey WT, Mechanick JI, Brett EM, et al. American Association of Clinical Endocrinologist and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patient with obesity. Endocr Pract. 2016;22(Suppl 3):1-203. https://pubmed.ncbi.nlm.nih.gov/27219496 https://doi.org/10.4158/EP161365.GL
Iacobini C, Pugliese G, Fantauzzi CB, Federici M, Menini S. Metabolically healthy versus metabolically unhealthy obesity. Metabolism. 2019;92:51-60. https://pubmed.ncbi.nlm.nih.gov/30458177 https://doi.org/10.1016/j.metabol.2018.11.009
Lin CJ, Chang YC, Cheng TY, Lo K, Liu SJ, Yeh TL. The association between metabolically healthy obesity and risk of cancer: a systematic review and meta-analysis of prospective cohort studies. Obesity Rev. 2020;21(10):e13049. https://pubmed.ncbi.nlm.nih.gov/32476278 https://doi.org/10.1111/obr.13049
Zheng X, Peng R, Xu H, et al. The association between metabolic status and risk of cancer among patients with obesity: metabolically healthy obesity vs. metabolically unhealthy obesity. Front Nutr. 2022;25(9):783660. https://pubmed.ncbi.nlm.nih.gov/35284439 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914254 https://doi.org/10.3389/fnut.2022.783660
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