Treatment Outcome of a β-hCG Secreting Intracranial Germ Cell Tumor in an Adult Filipino using Definitive Chemotherapy followed by Radiotherapy

A Case Report




Germ cell tumors (GCTs), germinoma, β hCG, hypopituitarism, diabetes insipidus


We report a case of a 24-year-old Filipino male who complained of general weakness, polydipsia, weight loss, bitemporal headaches, loss of libido and behavioral changes. Endocrine work-up revealed neurogenic diabetes insipidus and panhypopituitarism.  Brain MRI showed multiple intracranial tumors in the left frontal lobe, pineal and suprasellar region with moderate non-communicating hydrocephalus. Intracranial mass biopsy with ventriculo-peritoneal shunting was done. Histopathology of the mass and CSF revealed a germinoma. He underwent chemoradiotherapy while on maintenance hormone replacement.


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Author Biographies

Florence Rochelle Gan, University of Santo Tomas Hospital, Manila, Philippines

Section of Endocrinology, Diabetes and Metabolism

Maria Honolina Gomez, University of Santo Tomas Hospital, Manila, Philippines

Section of Endocrinology, Department of Medicine

Julie Ann Tapispisan, University of Santo Tomas Hospital, Manila, Philippines

Section of Oncology


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How to Cite

Gan, F. R., Gomez, M. H., & Tapispisan, J. A. (2022). Treatment Outcome of a β-hCG Secreting Intracranial Germ Cell Tumor in an Adult Filipino using Definitive Chemotherapy followed by Radiotherapy: A Case Report. Journal of the ASEAN Federation of Endocrine Societies, 37(1), 97–102.



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