CORRELATION STUDY BETWEEN ERYTHROCYTE ACETYLCHOLINESTERASE ACTIVITY, SERUM MALONDIALDEHYDE AND INSULIN SENSITIVITY IN AGRICULTURAL WORKERS AND NON-AGRICULTURAL WORKERS IN NAT-KAN VILLAGE, MAGWAY TOWNSHIP, MYANMAR

Authors

  • Mya Pwint Phyu Department of Physiology, University of Medicine, Magway, Myanmar
  • Zarchi Theint Hlaing Department of Physiology, University of Medicine, Magway, Myanmar
  • Thurein Zaw Department of Physiology, University of Medicine, Magway, Myanmar
  • Soe Minn Htway Department of Physiology, University of Medicine, Magway, Myanmar
  • Mya Thanda Sein Department of Physiology, University of Medicine 2, Yangon, Myanmar

Keywords:

AChE activity, HOMA-IR, MDA level, organophosphate pesticides exposure, agricultural workers

Abstract

INTRODUCTION
Many studies have indicated that organophosphate (OP) pesticides exposure was associated with hyperglycemia and development of type 2 diabetes mellitus in case studies and population studies. However, only few studies have examined the association between OP pesticides exposure and serum insulin level as well as insulin sensitivity.

OBJECTIVE
This study investigated the erythrocyte acetylcholinesterase activity, serum malondialdehyde and insulin sensitivity in agricultural workers and non-agricultural workers.

METHODOLOGY
The cross-sectional comparative study was undertaken in 45 agricultural workers and 45 non-agricultural workers from Nat-Kan village, Magway Township. Erythrocyte acetylcholinesterase (AChE) activity and serum Malondialdehyde (MDA) were measured by spectrophotometric method. Insulin sensitivity was calculated by Homeostasis model assessment (HOMA-IR).

RESULTS
Mean erythrocyte AChE activity was significantly lower in agricultural workers compared with non-agricultural workers (3553.99±855.60 U/L vs 4432.68±1287.86 U/L, p<0.001). A significant high level of serum MDA was observed in agricultural workers (0.74±0.05μmol/L vs 0.28±0.06 μmol/L, p<0.001). Median HOMA-IR value was significantly higher in agricultural workers [2.74 (2.37- 3.3)] than that of non-agricultural workers [2.28 (2.03-2.78), (p<0.05)]. The risk of insulin resistance was 2.8 times greater in agricultural workers than non-agricultural workers (Odd ratio=2.8; 95% confidence interval=1.18 to 6.72). Erythrocyte AChE activity had weak negative correlations with serum MDA level (r=-0.357, n=90, p<0.001) and HOMA-IR (ρ=- 0.305, n=90, p<0.05). There was a significant positive correlation between serum MDA level and HOMA-IR (ρ=0.355, n=90, p<0.001).

CONCLUSION
Organophosphate pesticides exposure decreased the erythrocyte AChE activity and increased oxidative stress. This oxidative stress partly attributed to the development of insulin resistance.

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Published

2022-05-02

How to Cite

Phyu, M. P., Hlaing, Z. T., Zaw, T., Htway, S. M., & Sein, M. T. (2022). CORRELATION STUDY BETWEEN ERYTHROCYTE ACETYLCHOLINESTERASE ACTIVITY, SERUM MALONDIALDEHYDE AND INSULIN SENSITIVITY IN AGRICULTURAL WORKERS AND NON-AGRICULTURAL WORKERS IN NAT-KAN VILLAGE, MAGWAY TOWNSHIP, MYANMAR. Journal of the ASEAN Federation of Endocrine Societies, 34(2), 6. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/1841

Issue

Vol. 34 No. 2 (2019): AFES Book of Abstracts (Supplement)

Section

Oral Research Presentations

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