POLYMORPHISM IN MTNR1B VARIANT GENE IS PROTECTIVE AGAINST GESTATIONAL DIABETES MELLITUS AMONG FILIPINO PREGNANT WOMEN

Abstract

INTRODUCTION
This study aimed to determine the association of rs10830963 polymorphism on the MTNR1B gene with insulin resistance (IR), insulin sensitivity (IS), and the risk of developing gestational diabetes mellitus (GDM) among Filipino pregnant women.

METHODOLOGY
A cross-sectional study was conducted involving 232 Filipino pregnant women, 72 GDM cases and 160 non-GDM women. DNA samples were extracted using a commercially available kit with slight modifications. Rs10830963 was genotyped using taqman allelic discrimination assay. Mann-Whitney U-test was used to determine the significant difference of various phenotypic characteristics between pregnant women with and without GDM. Person’s chisquare was used to determine the association of the said polymorphism with GDM. Lastly, odds ratio computation was used to determine the likelihood of developing GDM depending on the pregnant women’s genotypic and allelic characteristics.

CONCLUSION
The occurrence of rs10830963 polymorphism in MTNR1B gene is protective against the development of GDM among Filipino pregnant women but is not associated with insulin resistance nor insulin sensitivity.