POLYMORPHISM IN MTNR1B VARIANT GENE IS PROTECTIVE AGAINST GESTATIONAL DIABETES MELLITUS AMONG FILIPINO PREGNANT WOMEN

Authors

  • Maria Ruth Pineda-Cortel Department of Medical Technology, University of Santo Tomas, Manila, Philippines
  • Romar Dabban Department of Medical Technology, University of Santo Tomas, Manila, Philippines
  • Regine Due Department of Medical Technology, University of Santo Tomas, Manila, Philippines
  • Madelle Lopez Department of Medical Technology, University of Santo Tomas, Manila, Philippines
  • Gary Mamaid Department of Medical Technology, University of Santo Tomas, Manila, Philippines
  • Renielle Mangahas Department of Medical Technology, University of Santo Tomas, Manila, Philippines
  • Joseph Rafael Mauleon The Graduate School, University of Santo Tomas, Manila, Philippines
  • Nariwah Gaus Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines
  • Shamar Lo Lasta The Graduate School, University of Santo Tomas, Manila, Philippines

Keywords:

gestational diabetes mellitus, gene polymorphism, mtnr1b gene

Abstract

INTRODUCTION
 This study aimed to determine the association of rs10830963 polymorphism on the MTNR1B gene with insulin resistance (IR), insulin sensitivity (IS), and the risk of developing gestational diabetes mellitus (GDM) among Filipino pregnant women.

METHODOLOGY
A cross-sectional study was conducted involving 232 Filipino pregnant women, 72 GDM cases and 160 non-GDM women. DNA samples were extracted using a commercially available kit with slight modifications. Rs10830963 was genotyped using taqman allelic discrimination assay. Mann-Whitney U-test was used to determine the significant difference of various phenotypic characteristics between pregnant women with and without GDM. Person’s chisquare was used to determine the association of the said polymorphism with GDM. Lastly, odds ratio computation was used to determine the likelihood of developing GDM depending on the pregnant women’s genotypic and allelic characteristics.

CONCLUSION
The occurrence of rs10830963 polymorphism in MTNR1B gene is protective against the development of GDM among Filipino pregnant women but is not associated with insulin resistance nor insulin sensitivity.

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Author Biographies

Maria Ruth Pineda-Cortel, Department of Medical Technology, University of Santo Tomas, Manila, Philippines

The Graduate School, University of Santo Tomas, Manila, Philippines

Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines

Shamar Lo Lasta, The Graduate School, University of Santo Tomas, Manila, Philippines

Institute of Clinical Laboratory Sciences, Silliman University, Dumaguete City, Philippines

References

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Published

2022-06-02

How to Cite

Pineda-Cortel, M. R., Dabban, R. ., Due, R., Lopez, M., Mamaid, G., Mangahas, R., … Lasta, S. L. (2022). POLYMORPHISM IN MTNR1B VARIANT GENE IS PROTECTIVE AGAINST GESTATIONAL DIABETES MELLITUS AMONG FILIPINO PREGNANT WOMEN. Journal of the ASEAN Federation of Endocrine Societies, 34(2), 32. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/1969

Issue

Vol. 34 No. 2 (2019): AFES Book of Abstracts (Supplement)

Section

Abstracts of Original Articles | Prediabetes, Diabetes Mellitus, Hypoglycemia

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