ASSOCIATION OF CDKAL1 rs7756992 A/G HETEROGENOUS GENOTYPE WITH DEVELOPMENT OF GESTATIONAL DIABETES MELLITUS AMONG FILIPINO PREGNANT WOMEN
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*Abstract
INTRODUCTION
The presence of single nucleotide polymorphisms (SNPs) has been associated with different diseases. Although effects of CDKAL1 on glucose is not yet fully understood, it has been shown to enhance translation of beta cell transcripts, including proinsulin. In this study, We aimed to investigate the possible association between rs7754840 and rs7756992 of the CDKAL1 gene and GDM among Filipino pregnant women.
METHODOLOGY
A total of 193 patients were recruited, of which 102 women had GDM and 91 served as non-GDM controls. Oral glucose tolerance test (OGIT), lipid profile, and glycosylated hemoglobin (HbA1c) were performed. Rs7754840 and rs7756992 polymorphisms were genotyped using TaqMan allelic assays. The genotypic and allelic distributions of each SNP between GDM cases and controls, and the combined effects of alleles for the risk of developing GDM were analyzed.
CONCLUSION
The findings suggest the potential of CDKAL1 gene and rs7756992 polymorphisms as markers for GDM. Association between the CDKAL1 protein and development of GDM should be explored further.
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