ASSOCIATION OF CDKAL1 rs7756992 A/G HETEROGENOUS GENOTYPE WITH DEVELOPMENT OF GESTATIONAL DIABETES MELLITUS AMONG FILIPINO PREGNANT WOMEN

Authors

  • Maria Ruth Pineda-Cortel Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines
  • Karlo Baybayan Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines
  • Peter Louie Bello Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines
  • Latiffa Lois Camenforte Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines
  • Stefany Jane Ching Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines
  • Kathleen Conti Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines
  • Jeremiah Jose Ignacio Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines
  • Raphael Enrique Tiongco The Graduate School, University of Santo Tomas, Manila, Philippines
  • Jefferyl Kae Pandac The Graduate School, University of Santo Tomas, Manila, Philippines
  • Adrian Villavieja The Graduate School, University of Santo Tomas, Manila, Philippines

Keywords:

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Abstract

INTRODUCTION
The presence of single nucleotide polymorphisms (SNPs) has been associated with different diseases. Although effects of CDKAL1 on glucose is not yet fully understood, it has been shown to enhance translation of beta cell transcripts, including proinsulin. In this study, We aimed to investigate the possible association between rs7754840 and rs7756992 of the CDKAL1 gene and GDM among Filipino pregnant women.

METHODOLOGY
 A total of 193 patients were recruited, of which 102 women had GDM and 91 served as non-GDM controls. Oral glucose tolerance test (OGIT), lipid profile, and glycosylated hemoglobin (HbA1c) were performed. Rs7754840 and rs7756992 polymorphisms were genotyped using TaqMan allelic assays. The genotypic and allelic distributions of each SNP between GDM cases and controls, and the combined effects of alleles for the risk of developing GDM were analyzed.

CONCLUSION
The findings suggest the potential of CDKAL1 gene and rs7756992 polymorphisms as markers for GDM. Association between the CDKAL1 protein and development of GDM should be explored further.

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Author Biographies

Maria Ruth Pineda-Cortel, Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines

The Graduate School, University of Santo Tomas, Manila, Philippines

Research Center for the Natural and Applies Sciences, University of Santo Tomas, Manila Philippines

Jefferyl Kae Pandac, The Graduate School, University of Santo Tomas, Manila, Philippines

Institute of Clinical Laboratory Sciences, Silliman University,
Dumaguete City, Philippines

Adrian Villavieja, The Graduate School, University of Santo Tomas, Manila, Philippines

Research Center for the Natural and Applies Sciences, University of Santo Tomas, Manila Philippines

References

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Published

2022-06-02

How to Cite

Pineda-Cortel, M. R., Baybayan, K., Bello, P. L., Camenforte, L. L., Ching, S. J., Conti, K., Ignacio, J. J., Tiongco, R. E., Pandac, J. K., & Villavieja, A. (2022). ASSOCIATION OF CDKAL1 rs7756992 A/G HETEROGENOUS GENOTYPE WITH DEVELOPMENT OF GESTATIONAL DIABETES MELLITUS AMONG FILIPINO PREGNANT WOMEN. Journal of the ASEAN Federation of Endocrine Societies, 34(2), 33. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/1971

Issue

Vol. 34 No. 2 (2019): AFES Book of Abstracts (Supplement)

Section

Abstracts of Original Articles | Prediabetes, Diabetes Mellitus, Hypoglycemia

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