Pro12Ala POLYMORPHISM IN THE PPARG GENE IS ASSOCIATED WITH GESTATIONAL DIABETES AMONG FILIPINOS: A CROSS-SECTIONAL STUDY
Keywords:
gestational diabetes mellitus, rs1801282, pparg, FilipinoAbstract
INTRODUCTION
In this study, we determined the association between Pro12Ala polymorphism in the PPARG gene with gestational diabetes mellitus (GDM) among Filipinos. The association of the alleles and genotypes of the polymorphism with glycemia and insulin resistance was also determined.
METHODOLOGY
With ethical clearance, approximately 258 pregnant women (86 with GDM and 172 without GDM) were recruited. Whole blood was collected from each and was used for genomic DNA extraction. Laboratory tests such as oral glucose tolerance test, glycated hemoglobin (HbA1c), and insulin levels were performed. The extracted genomic DNA sample was subjected to allelic discrimination analysis using the TaqMan assay.
CONCLUSION
Overall, the Pro12Ala polymorphism of the PPARG gene may exhibit a protective role against GDM among selected Filipino women; however, further studies are needed to verify our claims.
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