Recurrent Desmoid Fibromatosis of the Thyroid Gland: A Diagnostic Challenge

Brijesh Kumar Singh; Sunil Chumber; Rathore Yashwant; Shipra Agarwal  Shipra; Sameer Rastogi; Surabhi Vyas

doi:10.15605/jafes.038.01.16

Authors

Brijesh Kumar Singh All India Institute of Medical Sciences, New Delhi, India https://orcid.org/0000-0002-9183-2317
Sunil Chumber All India Institute of Medical Sciences, New Delhi, India
Rathore Yashwant All India Institute of Medical Sciences, New Delhi, India
Shipra Agarwal Shipra All India Institute of Medical Sciences, New Delhi, India https://orcid.org/0000-0001-7037-4444
Sameer Rastogi All India Institute of Medical Sciences, New Delhi, India
Surabhi Vyas All India Institute of Medical Sciences, New Delhi, India

DOI:

https://doi.org/10.15605/jafes.038.01.16

Keywords:

thyroid, fibromatosis, immunohistochemistry, molecular, thyroid nodule

Abstract

A 31-year-old Indian female with a history of near-total thyroidectomy 2.5-years prior presented with recurrent neck swelling. Magnetic resonance imaging (MRI) of the neck revealed an infiltrating mass involving the thyroid bed. Biopsy from the mass and review of slides from the previous thyroidectomy revealed a spindle cell tumour with interspersed areas of fibrosis and infiltrative edges entrapping thyroid follicles. Beta-catenin immunopositivity and CTNNB1 mutation confirmed the diagnosis of fibromatosis. The case is being reported for its rarity and the discussion of its differential diagnoses.

Downloads

Download data is not yet available.

Author Biographies

Brijesh Kumar Singh, All India Institute of Medical Sciences, New Delhi, India

Senior Resident, Department of Surgical Disciplines

Sunil Chumber, All India Institute of Medical Sciences, New Delhi, India

Professor and Head, Department of Surgical Disciplines

Rathore Yashwant, All India Institute of Medical Sciences, New Delhi, India

Additional Professor, Department of Surgical Disciplines

Shipra Agarwal Shipra , All India Institute of Medical Sciences, New Delhi, India

Additional Professor, Department of Pathology

Sameer Rastogi, All India Institute of Medical Sciences, New Delhi, India

Additional Professor, Department of Medical Oncology

Surabhi Vyas, All India Institute of Medical Sciences, New Delhi, India

Additional Professor, Department of Radiodiagnosis

References

Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1-133. https://pubmed.ncbi.nlm.nih.gov/26462967. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739132. https://doi.org/10.1089/thy.2015.0020

WHO Classification of Tumors Editorial Board. Soft tissue and bone tumors. WHO Classification of Tumours, 5th ed. Lyon, France: International Agency for Research on Cancer (IARC), 2020.

Schwarzlmüller B, Hofstädter F. Fibromatosis of the thyroid gland region. An electron-microscopic and enzyme-histochemical study. Virchows Arch A Pathol Anat Histol. 1978;377(2):145-55. https://pubmed.ncbi.nlm.nih.gov/147558. https://doi.org/10.1007/bf00427002

Sinha AN, Rao AS, Sinha A, Arora R. Fibromatosis of thyroid gland—A case report. Indian J Otolaryngol Head Neck Surg. 1998;50(4):385-6. https://pubmed.ncbi.nlm.nih.gov/23119466. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451430. https://doi.org/10.1007/bf03000695

Samsi AB, Shah HK, Vaidya A, Pai PR, Deshmane U, Sane SY. Fibromatosis of thyroid gland (a case report). J Postgrad Med. 1992;38(1):36-7. https://pubmed.ncbi.nlm.nih.gov/1512725.

Simões-Pereira J, Cabrera RA, Leite V. A case of thyroid fibromatosis, a rare lesion of this gland. Endocrinol Diabetes Metab Case Rep. 2016;2016:16-0019. https://pubmed.ncbi.nlm.nih.gov/27855230. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093403. https://doi.org/10.1530/edm-16-0019

Mehdizadeh B, Gharib M. Thyroid fibromatosis: A case report. Endocr Regul. 2020;54(2):133-6. https://pubmed.ncbi.nlm.nih.gov/32597156. https://doi.org/10.2478/enr-2020-0016.

Zhang Z, Shi J, Yang T, Liu T, Zhang K. Management of aggressive fibromatosis. Oncol Lett. 2021;21(1):43. https://pubmed.ncbi.nlm.nih.gov/33262835. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693298. https://doi.org/10.3892/ol.2020.12304

Gronchi A, Colombo C, Le Péchoux C, et al; ISG and FSG. Sporadic desmoid-type fibromatosis: A stepwise approach to a non-metastasising neoplasm—A position paper from the Italian and the French Sarcoma Group. Ann Oncol. 2014;25(3):578-83. https://pubmed.ncbi.nlm.nih.gov/24325833. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433504. https://doi.org/10.1093/annonc/mdt485

de Bree E, Zoras O, Hunt JL, et al. Desmoid tumors of the head and neck: A therapeutic challenge. Head Neck. 2014;36(10):1517-26. https://pubmed.ncbi.nlm.nih.gov/24421052. https://doi.org/10.1002/hed.23496

Gounder MM, Mahoney MR, Van Tine BA, et al. Sorafenib for advanced and refractory desmoid tumors. N Engl J Med. 2018;379(25):2417-28. https://pubmed.ncbi.nlm.nih.gov/30575484. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447029. https://doi.org/10.1056/NEJMoa1805052

Papi G, Corrado S, Carapezzi C, De Gaetani C, Carani C. Riedel’s's thyroiditis and fibrous variant of Hashimoto's thyroiditis: A clinicopathological and immunohistochemical study. https://pubmed.ncbi.nlm.nih.gov/12906372. J Endocrinol Invest. 2003;26(5):444-9. https://doi.org/10.1007/BF03345200

Rebecchini C, Nobile A, Piana S, et al. Papillary thyroid carcinoma with nodular fasciitis-like stroma and β-catenin mutations should be renamed papillary thyroid carcinoma with desmoid-type fibromatosis. Mod Pathol. 2017;30(2):236-45. https://pubmed.ncbi.nlm.nih.gov/27713418. https://doi.org/10.1038/modpathol.2016.173