DIABETES AND HYPOPITUITARISM AS IMMUNE-RELATED ENDOCRINOPATHIES ASSOCIATED WITH PEMBROLIZUMAB THERAPY IN A PATIENT WITH ADVANCED RENAL CELL CARCINOMA

Authors

  • DShireen Lui Siow Leng
  • Azraai Bahari Nasruddin

Keywords:

pembrolizumab, diabetes, hypopituitarism

Abstract

CASE
We report a 59-year-old Malaysian-Chinese male with bilateral renal cell carcinoma with liver metastases who developed diabetes and hypopituitarism after approximately ten months on pembrolizumab. He presented with a one-week history of lethargy, polyuria, polydipsia, and nocturia. He was admitted to a private hospital as a case of diabetic ketoacidosis and was discharged with basal-bolus insulin. Three days after discharge, he was admitted to the oncology ward for uncontrolled diabetes without ketosis. Blood tests showed high serum glucose, low morning cortisol 11 nmol/L, low ACTH and low testosterone with inappropriately normal FSH and LH. He was diagnosed with diabetes, secondary adrenal insufficiency and hypogonadotropic hypogonadism. His condition improved after administration of basal-bolus insulin and hydrocortisone. He experienced spontaneous recovery of the gonadal axis after three months.

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Author Biographies

DShireen Lui Siow Leng

Putrajaya Hospital, Putrajaya, Malaysia

Azraai Bahari Nasruddin

Putrajaya Hospital, Putrajaya, Malaysia

References

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Published

2023-11-09

How to Cite

Leng, D. L. S. ., & Nasruddin , A. B. . (2023). DIABETES AND HYPOPITUITARISM AS IMMUNE-RELATED ENDOCRINOPATHIES ASSOCIATED WITH PEMBROLIZUMAB THERAPY IN A PATIENT WITH ADVANCED RENAL CELL CARCINOMA. Journal of the ASEAN Federation of Endocrine Societies, 38(S3), 70. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/3383

Issue

Vol. 38 No. S3 (2023): AFES Book of Abstracts (Supplement)

Section

Poster Presentation | Diabetes

License

Copyright (c) 2023 DShireen Lui Siow Leng, Azraai Bahari Nasruddin

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