Macroglossia: An Uncommon Manifestation of Primary Hypothyroidism due to Hashimoto's Thyroiditis in a Teenage Child
Keywords:macroglossia, short stature, delayed puberty, hypothyroidism
Thyroid disorders are prevalent in the paediatric population and untreated hypothyroidism leads to several adverse consequences like mental retardation, neurological impairment, short stature, delayed puberty and increased morbidity. Owing to a wide range of non-specific clinical manifestations, one must have a high index of suspicion for timely diagnosis and treatment of primary hypothyroidism. We describe the case of an adolescent girl who presented with short stature, delayed puberty and feeding difficulties owing to undiagnosed and subsequently untreated hypothyroidism.
Morreale de Escobar G.The role of thyroid hormone in fetal neurodevelopment. J Pediatr Endocrinol Metab. 2001;14(6):1453-62. PMID: 11837499.
Chandna S, Bathla M. Oral manifestations of thyroid disorders and its management. Indian J Endocrinol Metab. 2011;15(6):S113-6. https://doi.org/10.4103/2230-8210.83343.
Rivkees SA, Bode HH, Crawford JD. Long-term growth in juvenile acquired hypothyroidism: The failure to achieve normal adult stature. N Engl J Med. 1998;318:599–602.
Rosen DS, Foster C. Delayed puberty. Pediatr Rev.2001;22(9):309-15. https://doi.org/10.1542/pir.22-9-309.
Philip R, Saran S, Gutch M, Gupta KK. An unusual case of precocious puberty and macroorchidism. Thyroid Res Pract. 2013;10(1):29-31. https://doi.org/10.4103/0973-0354.105845.
Gutch M, Philip R, Philip R, Toms A, Saran S, Gupta KK. Skeletal manifestations of juvenile hypothyroidism and the impact of treatment on skeletal system. Indian J Endocrinol Metab. 2013; 17(7):181–3.https://doi.org/10.4103/2230-8210.119565.
Gutch M, Kumar S, Gupta KK, Syed RM, Gupta A, Bhattacharjee A, et al. Aetiology of short stature in northern India. J ASEAN Fed Endocr Soc. 2016;31(1):23.https://doi.org/10.15605/jafes.031.01.05.
Kumar S, Gutch M, Syed RM, Gupta AK, Gupta KK, Arya TVS. Prevalence and clinical profile of celiac disease in patients with type 1 diabetes mellitus in Western Uttar Pradesh, India. J ASEAN Fed Endocr Soc. 2015;30(2):142-6.https://doi.org/10.15605/jafes.030.02.02.
Gutch M, Kumar S, Razi SM, Gupta A, Kumar S, Gupta KK, Singh MM. Prevalence of short stature in juvenile hypothyroidism and the impact of treatment on various skeletal manifestation and growth velocity in a teritary care center. CHRISMED J Health Res. 2015;2(3):251-6. https://doi.org/10.4103/2348-3334.158704.
Rodríguez MER, García MAM, Flores IS. Congenital hypothyroidism and its oral manifestations. Revista Odontológica Mexicana. 2014;18(2):133-8. http://www.medigraphic.com/pdfs/odon/uo-2014/uoi142i.pdf.
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