THE RELATIONSHIP BETWEEN NUTRITIONAL STATUS, GLUCOSE AND LIPID LEVELS IN PULMONARY TUBERCULOSIS AND MULTI-DURG-RESISTANT TUBERCULOSIS IN PATIENTS WITH DIABETES MELLITUS

Abstract

INTRODUCTION
Diabetes mellitus (DM) poses a significant risk for development of active tuberculosis (TB) and a higher risk of developing multi-drug-resistant tuberculosis (MDR-TB). The purpose of this study was to analyze the correlation between nutritional status, glucose and lipid levels in pulmonary tuberculosis and multi-drug-resistant tuberculosis in persons with diabetes.

METHODOLOGY
The study was designed as a cross-sectional study of 69 patients with DM at Haji Adam Malik Hospital, divided into group 1 (n=37) for patients with TB and group 2 (n=32) for patients with MDR-TB, from the internal medicine ward from January to December 2018. Data included the patients’ demographic characteristics, history of illness, and clinical examination (BMI). Laboratory tests for evaluation of glucose (FPS, PPS, HbA1C), albumin, lipids (Total Cholesterol, TG, LDL-C and HDL-C,). Spearman and Pearson correlation tests were used to correlate numerical variables.

RESULTS
The average age for group 1 was 56,16+8,55 years old, and 52,41+8,38 years old for group 2. Diabetes duration, BMI, albumin, HbA1C and HDL-C were significantly different between group 1 and group 2 (p<0,005). In group 2, the duration of diabetes, HbA1C, BMI and albumin were significantly higher compared to group 1. A significant correlation was found between HbA1C and BMI (r=-0.357, p=0.030), HbA1c with albumin (p=0.037, r=-0.315) but no correlation with lipids (p>0.05).

CONCLUSION
In diabetes mellitus with TB and MDR-TB, HbA1C correlated significantly with BMI and albumin.