Self-Reported Hypoglycemia in Insulin-Treated Patients with Diabetes: Results from the Philippines Cohort of the International Operations Hypoglycemia Assessment Tool (IO HAT) Study

Authors

Keywords:

International Operations Hypoglycemia Assessment Tool, insulin-treated patients with diabetes, hypoglycemia, Philippines

Abstract

*Visual Abstracts prepared by Dr. Monica Therese Cating-Cabral

Objective. To determine the frequency of hypoglycemia in insulin-treated patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) in the non-interventional International Operations Hypoglycemia Assessment Tool (IO HAT) study.

Methodology.This sub-analysis included Filipino patients with T1DM or T2DM, aged 18 years and older, treated with insulin for more than 12 months, who completed the two-part self-assessment questionnaires (SAQ1 and SAQ2) and patient diaries that recorded hypoglycemia during retrospective (6 months/4 weeks before baseline) and prospective period (4 weeks after baseline) (ClinicalTrials.gov number: NCT02306681).

Results. A total of 671 patients were enrolled and completed the SAQ1 (62 patients with T1DM and 609 patients with T2DM). Almost all patients (100% in T1DM and 99.3% in T2DM) experienced at least 1 hypoglycemic event prospectively. The incidence of any hypoglycemia was also high in the prospective period compared to retrospective period (72.6 [95% CI: 64.8, 80.9] events PPY and 43.6 [95% CI: 37.8, 49.9] events PPY; p=0.001, respectively) in T1DM patients.

Conclusion. Among insulin-treated patients, higher rates of hypoglycemia were reported prospectively than retrospectively. This indicates that the patients in real-life setting often under report hypoglycemia. Patient education can help in accurate reporting and appropriate management of hypoglycemia and diabetes.

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Author Biographies

Roberto Mirasol, St. Luke's Medical Center, Quezon City Manila Doctors Hospital

Section Chief, Section of Endocrinology Diabetes and Metabolism, St Luke's Medical Center, Quezon City

Nemencio Nicodemus Jr., University of the Philippines Manila

Professor, Department of Biochemistry

Clinical Associate Professor, Department of Medicine

Anand Jain, Novo Nordisk Healthcare AG, Zurich

Senior Medical Manager

Arvind Vilas Gadekar, Novo Nordisk Pharma Operations (BAOS) Sdn. Bhd., Kuala Lumpur

Regional Medical Advisor

Susan Yu-Gan, Metropolitan Medical Center, Manila

Consultant in Endocrinology

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Published

2018-03-08

How to Cite

Mirasol, R., Nicodemus Jr., N., Jain, A., Gadekar, A. V., & Yu-Gan, S. (2018). Self-Reported Hypoglycemia in Insulin-Treated Patients with Diabetes: Results from the Philippines Cohort of the International Operations Hypoglycemia Assessment Tool (IO HAT) Study. Journal of the ASEAN Federation of Endocrine Societies, 33(1), 12. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/429

Issue

Vol. 33 No. 1 (2018): May Issue

Section

Original Articles

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