Prevalence of Hypoglycaemia among Insulin-Treated Pregnant Women with Diabetes- who achieved Tight Glycaemic Control

Keywords: hypoglycaemia, continuous glucose monitoring system, pregnancy, diabetes mellitus


Objective.To determine the prevalence of hypoglycaemia using continuous glucose monitoring system (CGMS) among insulin-treated pregnant women with diabetes whose glycosylated haemoglobin (HbA1c) were

Methodology.We conducted a cross-sectional study using 6-days CGMS to detect the prevalence of hypoglycaemia in 31 insulin-treated pregnant women with diabetes who achieved HbA1c

Results. Eight women experienced confirmed hypoglycaemia with additional seven experienced relative hypoglycaemia, giving rise to prevalence rate of 45.2% (one had both confirmed and relative hypoglycaemia). Nine relative hypoglycaemia and 17 confirmed hypoglycaemic events were recorded. Sixteen (94%) out of 17 confirmed hypoglycaemia events recorded by CGMS were asymptomatic and were missed despite performing regular SMBG. Nocturnal hypoglycaemia events were recorded in seven women. Univariable analysis did not identify any association between conventional risk factors and hypoglycaemia events in our cohort.

Conclusion. Insulin-treated pregnant women with diabetes who achieved HbA1c < 6.0% were associated with high prevalence of hypoglycaemia. Asymptomatic hypoglycaemia is common in our cohort and frequently missed despite regular SMBG. Present study did not identify any association between conventional risk factors and hypoglycaemia events in our cohort.


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Author Biographies

Danish Ng, Tengku Ampuan Rahimah Hospital, Klang, Ministry of Health
Department of Medicine
Nurain Mohd Noor, Putrajaya Hospital, Ministry of Health
Department of Medicine
Sy Liang Yong, Tengku Ampuan, Rahimah Hospital, Klang, MInistry of Health
Department of Medicine


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How to Cite
Ng, D., Mohd Noor, N., & Yong, S. L. (2019). Prevalence of Hypoglycaemia among Insulin-Treated Pregnant Women with Diabetes- who achieved Tight Glycaemic Control. Journal of the ASEAN Federation of Endocrine Societies, 34(1), 29.
Original Articles