A Systematic Review on the Association between Lipid Accumulation Product Index and Type 2 Diabetes Mellitus

  • Gratcia Ayundini Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine University of Indonesia http://orcid.org/0000-0002-7035-0829
  • Cindy Astrella Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine University of Indonesia
  • Dicky Tahapary Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine University of Indonesia Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine University of Indonesia http://orcid.org/0000-0002-4048-5159
  • Pradana Soewondo Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine University of Indonesia Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine University of Indonesia http://orcid.org/0000-0003-3674-7934
Keywords: lipid accumulation product, type 2 diabetes mellitus, insulin resistance, obesity

Abstract

Introduction. Excess of fat accumulation contributes to the development of type 2 diabetes mellitus (T2DM). Lipid accumulation product (LAP) index is an index computed from waist circumference and triglycerides, which represents increased lipotoxicity. We aim to study the relationship of LAP index and T2DM and its potency as a predictor for T2DM development.

Methodology. All studies retrieved during literature search in PubMed and Cochrane database using the terms of lipid accumulation product, LAP and T2DM reporting the association between LAP and T2DM were reviewed.

Results. Two cross-sectional studies and 1 cohort study in Japan, USA and Iran respectively were obtained. In Japan, the cut off values were different, 21.1 for women and 37.2 for men. A high LAP corresponds to a higher risk of T2DM [19.1 (6.6 – 55.5) for women and 7.4 (5.1 – 10.8) for men].

Conclusion. LAP has strong association with T2DM but its ability to predict the incidence of T2DM needs to be confirmed.

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Author Biography

Pradana Soewondo, Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine University of Indonesia Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine University of Indonesia
Associate Professor
Published
2019-07-30
How to Cite
Ayundini, G., Astrella, C., Tahapary, D., & Soewondo, P. (2019). A Systematic Review on the Association between Lipid Accumulation Product Index and Type 2 Diabetes Mellitus. Journal of the ASEAN Federation of Endocrine Societies, 34(1), 16. https://doi.org/10.15605/jafes.034.01.04
Section
Review Articles