METABOLIC CHARACTERISTICS OF PATIENTS WITH POLYCYSTIC OVARY SYNDROME IN A PERUVIAN HOSPITAL

Abstract

OBJECTIVES
To describe the metabolic characteristics of patients with PCOS in the endocrinology service of a Peruvian hospital.

METHODOLOGY
Descriptive study that evaluated the clinical and metabolic characteristics of patients with PCOS in the endocrino- logy service of the Edgardo Rebagliati Martins National Hospital, Lima - Peru.

RESULTS
We evaluated 100 consecutive women; age 27.2 ± 7.3 years; 4% and 7% had DM2 and hypertension, respectively. 66% had a family history of DM2, 37% hypertension, 38% obesity, and 9% early cardiovascular disease. Twelve women had macrosomic children. Their BMI: 27.9 ± 6.4 g/m2; 68% had a BMI >25 kg/m2, 47% had a waist circumference > 88 cm, and 37% had acanthosis nigricans. Fasting blood glucose: 91,9 ± 23,4 (range: 68–214 mg/dL); fasting insulin and 2 hours post-load: 15,8 ± 11,2 (range: 2,7–77,4) and 59,3 ± 59,7 (range: 8,4–400), respectively. Some 15% presented with basal hyperglycemia >100 mg/dL and 42% had basal hyperinsulinemia >12,5 uIU/ml.
Forty six percent had HOMA-IR >2,5; 66% had QUICKI <0,357 and 22% had a Glucose/Insulin ratio <4,5. HOMA- %B fluctuated between 30,9 and 928.8%; 28% had HOMA- %B <100% and 23% HOMA-%B >300%. 62% had OGIS method <405 and 32% ISI-composite <3.
HDLc and triglyceride concentrations were 45 ± 11,4 (range: 20–79 mg/dL) and 123 ± 75,3 (32–390 mg/dL), respectively. 54% had HDLc <50 mg/dL and 25% had triglycerides >150 mg/dL.

CONCLUSION
Increased weight, positive family history and metabolic alterations are frequent in PCOS. The different surrogates for establishing insulin resistance, both fasting and during oral glucose load, are variable. It is important to establish the PCOS phenotype present in each patient.