Insulin Resistance and β-Cell Function of Lean versus Overweight or Obese Filipino Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Keywords: type 2 diabetes mellitus, insulin resistance, beta-cell function, lean, overweight, obese


Objectives. To compare the level of insulin resistance and β-cell function between lean and overweight/obese Filipino patients with newly diagnosed type 2 diabetes mellitus (T2DM).

Methodology. This was a cross-sectional analytical study including newly diagnosed T2DM Filipino patients from St. Luke’s Medical Center - Quezon City. The patients were classified as either lean or overweight/obese. Age, sex, smoking history, anthropometric measures and blood pressure were obtained. Insulin resistance and β-cell function were determined using the homeostasis model assessment (HOMA). The original model (HOMA1) and the updated model (HOMA2) were used.

Results. A total of 80 subjects were included. There were 40 subjects in each group. The overweight/obese subjects had significantly higher mean insulin resistance (HOMA1-IR 9.8±11.7, HOMA2-IR 3.0±2.0) compared to the lean group (HOMA1-IR 2.9±1.5, HOMA2-IR 1.3±0.5). This was consistent in both HOMA1 and HOMA2 (p-values=0.001 and p-value=0.003), but not in HOMA2 (lean=57.6±30.5, overweight/obese=74.8±45.7, p-value=0.051). Overweight/obesity increased HOMA1-IR by 4.0 and HOMA1-B by 46.1 (p-values= 0.002 and p-valuesp-value=0.005; HOMA2-IR adjOR=10.9, 95%CI=3.4-34.9, p-valuep-value=0.033; HOMA2-B adjOR=0.2, 95%CI=0.04-0.9, p-value=0.043) compared to being lean.

Conclusion. Newly diagnosed overweight/obese T2DM had higher mean insulin resistance and β-cell function compared to lean T2DM. Overweight/obesity was also associated with higher odds of developing insulin resistance and lower odds for a decreased β-cell function compared to being lean. The overweight/obese T2DM group also had worse metabolic profile manifested by higher FPG, HbA1c, SGPT and blood pressures compared to the lean T2DM group.


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Author Biographies

Francesca Paula Bautista, St. Luke's Medical Center, Quezon City

Section of Endocrinology, Diabetes and Metabolism

Department of Medicine

Gabriel Jasul Jr., St. Luke's Medical Center, Quezon City

Section of Endocrinology, Diabetes and Metabolism

Department of Medicine

Oliver Allan Dampil, St. Luke's Medical Center, Quezon City

Section of Endocrinology, Diabetes and Metabolism

Department of Medicine


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How to Cite
Bautista, F. P., Jasul Jr., G., & Dampil, O. A. (2019). Insulin Resistance and β-Cell Function of Lean versus Overweight or Obese Filipino Patients with Newly Diagnosed Type 2 Diabetes Mellitus. Journal of the ASEAN Federation of Endocrine Societies, 34(2), 164-170.
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